Loricrin Recombinant Rabbit Monoclonal Antibody
Catalog# IRS165RB
Loricrin Recombinant Rabbit Monoclonal Antibody
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mIHC
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Mouse
-
unconjugated
Overview
Product Name
Loricrin Recombinant Rabbit Monoclonal Antibody
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Synthetic peptide within Human Loricrin aa 1-100.
Species Reactivity
Mouse
Validated Applications
mIHC
Molecular Weight
Predicted band size: 26 kDa
Positive Control
Mouse skin tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
mIHC
-
1:100
Target
Function
Defects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK) [MIM:133200]. Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques. Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.
Background References
1. Ishitsuka Y et al. Loricrin at the Boundary between Inside and Outside. Biomolecules. 2022 May
2. Ishitsuka Y et al. Loricrin: Past, Present, and Future. Int J Mol Sci. 2020 Mar
Subcellular Location
Cytoplasm. Nucleus.
UNIPROT
Synonyms
LOR antibody
LOR protein antibody
LORI_HUMAN antibody
Loricrin antibody
LRN antibody
MGC111513 antibody
OTTHUMP00000015823 antibody
Images
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mIHC analysis of mouse skin tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-Loricrin antibody (IRS165RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"