MUC1 Mouse Monoclonal Antibody
Catalog# IRS174MS
MUC1 Mouse Monoclonal Antibody
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mIHC
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Human
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unconjugated
Overview
Product Name
MUC1 Mouse Monoclonal Antibody
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Synthetic peptide of core peptide domain of human MUC1.
Species Reactivity
Human
Validated Applications
mIHC
Molecular Weight
Predicted band size: 122 kDa
Positive Control
Human tonsil tissue, human colon tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
Isotype
IgG2a
Purification Method
Protein A affinity purified.
Application Dilution
-
mIHC
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1:100
Target
Function
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
Background References
1. Taylor-Papadimitriou J. et. al. Latest developments in MUC1 immunotherapy. Biochem Soc Trans. 2018 Jun
2. Kato K. et. al. MUC1: The First Respiratory Mucin with an Anti-Inflammatory Function. J Clin Med. 2017 Nov
Subcellular Location
Apical cell membrane. Secreted. Nucleus, Cell membrane, Cytoplasm.
UNIPROT
Synonyms
ADMCKD antibody
ADMCKD1 antibody
Breast carcinoma associated antigen DF3 antibody
Breast carcinoma-associated antigen DF3 antibody
CA 15-3 antibody
CA15 3 antibody
CA15 3 antigen antibody
CA15-3 antibody
CA15.3 antibody
Cancer antigen 15-3 antibody
ExpandImages
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mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with Mouse anti-MUC1 antibody (IRS174MS) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900809). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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mIHC analysis of human colon tissue (Formalin/PFA-fixed paraffin-embedded sections) with Mouse anti-MUC1 antibody (IRS174MS) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900809). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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