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MUC1 Mouse Monoclonal Antibody (IRS174MS)

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Catalog# IRS174MS

Mouse Monoclonal to MUC1

Tested for

  • mIHC

Reacts with

  • Human

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Specifications

Product Type

Mouse monoclonal primary

Product Name

MUC1 Mouse Monoclonal Antibody (IRS174MS)

Immunogen

Synthetic peptide of core peptide domain of human muc1.

Host

Mouse

Positive Control

Human tonsil tissue, human colon tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

APPLICATION DILUTION

  • mIHC

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4C. Store at +4C short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20C long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 122 kDa

Isotype

IgG2a

TARGET

UNIPROT #

P15941

PROTEIN NAME

MUC1

SYNONYMS

ADMCKD antibody;ADMCKD1 antibody;Breast carcinoma associated antigen DF3 antibody;Breast carcinoma-associated antigen DF3 antibody;CA 15-3 antibody;CA15 3 antibody;CA15 3 antigen antibody;CA15-3 antibody;CA15.3 antibody;Cancer antigen 15-3 antibody;Carcinoma associated mucin antibody;Carcinoma-associated mucin antibody;CD 227 antibody;CD227 antibody;DF3 antigen antibody;EMA antibody;Episialin antibody;Epithelial Membrane Antigen antibody;H23 antigen antibody;H23AG antibody;KL 6 antibody;KL-6 antibody;KL6 antibody;Krebs von den Lungen-6 antibody;MAM 6 antibody;MAM6 antibody;MCD antibody;MCKD antibody;MCKD1 antibody;Medullary cystic kidney disease 1 (autosomal dominant) antibody;Medullary cystic kidney disease, autosomal dominant antibody;MUC 1 antibody;MUC-1 antibody;MUC-1/SEC antibody;MUC-1/X antibody;MUC1 antibody;MUC1-alpha antibody;MUC1-beta antibody;MUC1-CT antibody;MUC1-NT antibody;MUC1/ZD antibody;MUC1_HUMAN antibody;Mucin 1 antibody;Mucin 1 cell surface associated antibody;Mucin 1 transmembrane antibody;Mucin 1, cell surface associated antibody;Mucin-1 subunit beta antibody;Peanut reactive urinary mucin antibody;Peanut-reactive urinary mucin antibody;PEM antibody;PEMT antibody;Polymorphic epithelial mucin antibody;PUM antibody;Tumor associated epithelial membrane antigen antibody;Tumor associated epithelial mucin antibody;Tumor associated mucin antibody;Tumor-associated epithelial membrane antigen antibody;Tumor-associated mucin antibody

SUBCELLULAR LOCATION

Apical cell membrane. Secreted. Nucleus, Cell membrane, Cytoplasm.

FUNCTION

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

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