SLC12A1 / NKCC2 Recombinant Rabbit Monoclonal Antibody (IRS181RB)

UNIPROT #

Q13621

PROTEIN NAME

SLC12A1 / NKCC2

SYNONYMS

BSC1 antibody;Bumetanide sensitive sodium 3 antibody;Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 antibody;Kidney specific Na K Cl symporter antibody;Kidney-specific Na-K-Cl symporter antibody;MGC48843 antibody;Na K 2Cl cotransporter antibody;NKCC2 antibody;potassiumchloride cotransporter 2 antibody;S12A1_HUMAN antibody;Slc12a1 antibody;sodium potassium chloride cotransporter 2 antibody;solute carrier family 12 (sodium/potassium/chloride transporters) antibody;Solute carrier family 12 member 1 antibody

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

The Na-K-2Cl cotransporter (NKCC2) is a sodium-potassium-chloride cotransporter. It is mainly expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop (TALH) and mediates the majority of NaCl resorption and concentration of urine. NKCC2 is the target for several diuretic drugs, such as bumetanide, and is involved in the pathogenesis of hypertension. Mutations in the NKCC2-encoding gene, SLC12A1, causes Bartter’s syndrome, which is featured by impaired salt reabsorption in the TALH, hypokalemic metabolic alkalosis, and hypercalciuria . Recently, NKCC2 was reported to be expressed in the brain hypothalamo-neurohypophyseal system (HNS) and upregulated upon osmotic stress.