Occludin Recombinant Rabbit Monoclonal Antibody (IRS183RB)

UNIPROT #

Q61146

PROTEIN NAME

Occludin

SYNONYMS

BLCPMG antibody;FLJ08163 antibody;FLJ18079 antibody;FLJ77961 antibody;FLJ94056 antibody;MGC34277 antibody;Occludin antibody;Ocln antibody;OCLN_HUMAN antibody;Tight junction protein occludin antibody

SUBCELLULAR LOCATION

Cell membrane, tight junction.

FUNCTION

Occludin is an integral membrane protein closely associated with the tight junctions of epithelial and endothelial cells. Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of occludin. Expression of occludin is up-regulated by poly-unsaturated fatty acids, increasing transendothelial cell resistance and reducing cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.