RAGE Recombinant Rabbit Monoclonal Antibody

Function

Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions, including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 ras and MAP kinase, which leads to activation of transcription.

Background References

1. Kim J et al. Cytoplasmic translocation of high-mobility group box-1 protein is induced by diabetes and high glucose in retinal pericytes. Mol Med Rep 14:3655-61 (2016).

2. Yao X et al. Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model. PLoS One 10:e0139416 (2015).

Subcellular Location

Cell membrane, Secreted.

UNIPROT

SwissProt: Q15109 Human

Synonyms

Advanced glycosylation end product-specific receptor antibody

Ager antibody

MGC2235 antibody

RAGE_HUMAN antibody

Receptor for advanced glycosylation end products antibody