SST/Somatostatin 28 Recombinant Rabbit Monoclonal Antibody

Function

Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin inhibits insulin and glucagon secretion. Somatostatin has two active forms produced by the alternative cleavage of a single preproprotein: one consisting of 14 amino acids, the other consisting of 28 amino acids. Among the vertebrates, there exist six different somatostatin genes that have been named SS1, SS2, SS3, SS4, SS5 and SS6. Zebrafish have all six. The six different genes, along with the five different somatostatin receptors, allow somatostatin to possess a large range of functions. Humans have only one somatostatin gene, SST.

Background References

1. Ampofo E et al. Regulatory Mechanisms of Somatostatin Expression. Int J Mol Sci. 2020 Jun

2. Duque-Díaz E et al. Distribution of somatostatin-28 (1-12), calcitonin gene-related peptide, and substance P in the squirrel monkey brainstem: an immunocytochemical study. Anat Sci Int. 2019 Jan

Subcellular Location

Secreted.

UNIPROT

SwissProt: P61278 Human

Synonyms

Growth hormone release inhibiting factor antibody

SMST antibody

Somatostatin 28 antibody

Somatostatin antibody

SST antibody