Villin1 Recombinant Rabbit Monoclonal Antibody

Function

Caldesmon, Filamin 1, Nebulin and Villin are differentially expressed and regulated Actin binding proteins. Both muscular (CDh) and non-muscular (CDl) forms of Caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and myosin. CDh is expressed predominantly on thin filaments in smooth muscle, whereas CDl is widely expressed in non-muscle tissues and cells. Filamin 1, which is ubiquitously expressed and exists as a homodimer, functions to crosslink Actin to filaments. Nebulin is a large filamentous protein specific to muscle tissue that may function as a ruler for filament length. Several isoforms of Nebulin are produced by alternative exon usage. Villin is Ca2+-regulated and is the major structural component of the brush border of absorptive cells.

Background References

1. Northrop J et al. Different calcium dependence of the capping and cutting activities of villin. J Biol Chem 261:9274-9281 (1986).

2. Zhai L et al. Tyrosine phosphorylation of villin regulates the organization of the actin cytoskeleton. J Biol Chem 276:36163-36167 (2001).

Subcellular Location

Cytoskeleton.

UNIPROT

SwissProt: Q62468 Mouse

Synonyms

D2S1471 antibody

OTTHUMP00000164145 antibody

VIL antibody

VIL1 antibody

VILI_HUMAN antibody

Villin 1 antibody

Villin-1 antibody

Villin1 antibody