ROR alpha / RORA Recombinant Rabbit Monoclonal Antibody
Catalog# IRS258RB
ROR alpha / RORA Recombinant Rabbit Monoclonal Antibody
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mIHC
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Mouse
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unconjugated
Overview
Product Name
ROR alpha / RORA Recombinant Rabbit Monoclonal Antibody
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Recombinant fragment.
Species Reactivity
Mouse
Validated Applications
mIHC
Molecular Weight
Predicted band size: 59 kDa
Positive Control
Mouse brain tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
mIHC
-
1:100
Target
Function
RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is encoded by the RORA gene. RORα participates in the transcriptional regulation of some genes involved in circadian rhythm. In mice, RORα is essential for development of cerebellum through direct regulation of genes expressed in Purkinje cells. It also plays an essential role in the development of type 2 innate lymphoid cells (ILC2) and mutant animals are ILC2 deficient. In addition, although present in normal numbers, the ILC3 and Th17 cells from RORα deficient mice are defective for cytokine production.
Background References
1. Liu D et al. The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression. Cancer Res. 2024 Jul
2. Li M et al. The single-cell transcriptomic atlas and RORA-mediated 3D epigenomic remodeling in driving corneal epithelial differentiation. Nat Commun. 2024 Jan
Subcellular Location
Nucleus.
UNIPROT
Synonyms
fhl2a antibody
NR1F1 antibody
Nuclear receptor ROR alpha antibody
Nuclear receptor ROR-alpha antibody
Nuclear receptor RZR-alpha antibody
Nuclear receptor subfamily 1 group F member 1 antibody
RAR related orphan receptor A antibody
RAR related orphan receptor alpha antibody
RAR-related orphan receptor A antibody
Retinoid-related orphan receptor-alpha antibody
ExpandImages
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mIHC analysis of mouse brain tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-ROR alpha / RORA antibody (IRS258RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"