LRP-1 Mouse Monoclonal Antibody [A4-F5]

Function

The LDL receptor-related protein (LRP1) is a large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of the LDL receptor family that plays diverse roles in various biological processes including lipoprotein metabolism, degradation of proteases, activation of lysosomal enzymes, and cellular entry of bacterial toxins and viruses.

Background References

1. "Functional expression of murine LRP1 requires correction of Lrp1 cDNA sequences."Smeijers L., Willems S., Lauwers A., Thiry E., van Leuven F., Roebroek A.J.M.Biochim. Biophys. Acta 1577:155-158(2002)

2. “Functional expression of the alpha 2-macroglobulin receptor CD91 in salivary gland epithelial cells.” Bourazopoulou,E; Moutsopoulos,HM;Tzioufas,AG。Journal of Autoimmunity . 2009vol.33(no.2)

Sequence Similarity

Belongs to the LDLR family.

Post-translational Modification

Phosphorylated on serine and threonine residues.; Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1 (By similarity).; Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane (By similarity).

Subcellular Location

cell membrane.

UNIPROT

SwissProt: Q91ZX7 Mouse

Synonyms