SOX10 Mouse Monoclonal Antibody [1-11]
Catalog# M1311-1
SOX10 Mouse Monoclonal Antibody [1-11]
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WB
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IHC-P
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Mouse
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unconjugated
Overview
Product Name
SOX10 Mouse Monoclonal Antibody [1-11]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Recombinant protein within human SOX10 aa 80-310.
Species Reactivity
Mouse
Validated Applications
WB, IHC-P
Molecular Weight
Predicted band size: 50 kDa
Positive Control
F9, mouse fetal brain
Conjugation
unconjugated
Clone Number
1-11
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1:500-1:1000
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IHC-P
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1:50
Target
Function
Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease
Background References
1. Pingault V et al. SOX10: 20 years of phenotypic plurality and current understanding of its developmental function. J Med Genet. 2022 Feb
2. Yoon EC et al. TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma. Hum Pathol. 2022 Jul
Tissue Specificity
Expressed in oligodendroglia of the spinal tube (at protein level).
Subcellular Location
Nucleus, cytoplasm
UNIPROT
Synonyms
DOM antibody
DOM antibody
Dominant megacolon mouse human homolog of antibody
MGC15649 antibody
PCWH antibody
SOX 10 antibody
SOX10 antibody
SOX10_HUMAN antibody
SRY (sex determining region Y) box 10 antibody
SRY (sex determining region Y) box 10 antibody
ExpandImages
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Western blot analysis on F9 (1) and mouse fetal brain (2) cell lysates using anti-SOX10 Mouse mAb.
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Immunohistochemical analysis of paraffin-embedded mouse fetal brain (13.5 days) tissue using anti- SOX10 Mouse mAb.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"