SOX10 Recombinant Rabbit Monoclonal Antibody [SN20-41]

Function

Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

Background References

1. Guye P et al. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Nat Commun 7:10243 (2016).

2. Arts N et al. microRNA-155, induced by interleukin-1 , represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. PLoS One 10:e0122517 (2015).

Tissue Specificity

Expressed in fetal brain and in adult brain, heart, small intestine and colon.

Subcellular Location

Cytoplasm, Nucleus, Mitochondrion outer membrane.

UNIPROT

SwissProt: P56693 Human

SwissProt: Q04888 Mouse

SwissProt: O55170 Rat

Synonyms