MASP2 Mouse Monoclonal Antibody [F3-4] (M1501-11)

UNIPROT #

O00187

PROTEIN NAME

MASP2

SYNONYMS

Mannan binding lectin serine peptidase 2 antibody;Mannan binding lectin serine protease 2 antibody;Mannose binding protein associated serine protease 2 antibody;MAP 19 antibody;MAP19 antibody;MASP 2 antibody;MBL associated plasma protein of 19 kD antibody;MBL associated serine protease 2 antibody;Small MBL associated protein antibody;sMAP antibody

SEQUENCE SIMILARITIES

Belongs to the ku70 family.

DEVELOPMENTAL STAGE

Expression does not increase during promyelocyte differentiation.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.; ADP-ribosylated by PARP3.

SUBCELLULAR LOCATION

Secreted

FUNCTION

Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene. MASP-2 involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.