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Lamin B2 Mouse Monoclonal Antibody [J9-C4] (M1505-10)

Price: Regular price $350.00

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Catalog# M1505-10

Mouse Monoclonal to Lamin B2

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

Specifications

Product Type

Mouse monoclonal primary

Product Name

Lamin B2 Mouse Monoclonal Antibody [J9-C4] (M1505-10)

Immunogen

Synthetic peptide within human lamin b2 aa 1-50 / 620.

Host

Mouse

Positive Control

Jurkat cell lysates, human lung cancer tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

J9-C4

RRID

AB_3073101

APPLICATION DILUTION

  • WB

  • 1:1,000-1:2,000

  • IHC-P:1:500-1:2,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 70 kDa

Isotype

IgG1

TARGET

UNIPROT #

Q03252

PROTEIN NAME

Lamin B2

SYNONYMS

LAMB 2 antibody;LAMB2 antibody;Lamin-B2 antibody;LMN 2 antibody;LMN B2 antibody;LMN2 antibody;LMNB 2 antibody;LMNB2 antibody;LMNB2_HUMAN antibody;MGC2721 antibody;RGD1563803 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

POST-TRANSLATIONAL MODIFICATION

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

SUBCELLULAR LOCATION

Nucleus lamina.

FUNCTION

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

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