Neuropilin 1 Mouse Monoclonal Antibody [A3-D1]

Function

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development.

Background References

1. "A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain."Stoehr H., Berger C., Froehlich S., Weber B.H.F.Gene 286:223-231(2002)

2. "Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system." Michishita M., Ikeda T., Nakashiba T., Ogawa M., Tashiro K., Honjo T., Doi K., Itohara S., Endo S.Brain Res. Dev. Brain Res. 153:135-142(2004)

Sequence Similarity

Belongs to the neuropilin family.

Tissue Specificity

The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Subcellular Location

Cell membrane, Cytoplasm, Secreted.

UNIPROT

SwissProt: O14786 Human

SwissProt: P97333 Mouse

Synonyms