Nucleoporin p62 Recombinant Rabbit Monoclonal Antibody [JE55-09]

Function

Nuclear pore glycoprotein p62 is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues, followed by association with other complex proteins. In humans it is encoded by the NUP62 gene. The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.

Background References

1. Gleixner AM et al. NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility. Nat Commun. 2022 Jun

2. Nag N et al. Mislocalization of Nup62 Contributes to TDP-43 Proteinopathy in ALS/FTLD. ACS Chem Neurosci. 2022 Sep

Subcellular Location

Nucleus, nuclear pore complex, Cytoplasm, cytoskeleton, spindle pole, Nucleus envelope, microtubule organizing center, centrosome.

UNIPROT

SwissProt: P37198 Human

SwissProt: Q63850 Mouse

SwissProt: P17955 Rat

Synonyms