PKC zeta Recombinant Rabbit Monoclonal Antibody [PSH06-74]

Function

Protein kinase C, zeta (PKCζ), also known as PRKCZ, is a protein in humans that is encoded by the PRKCZ gene. The PRKCZ gene encodes at least two alternative transcripts, the full-length PKCζ and an N-terminal truncated form PKMζ. PKMζ is thought to be responsible for maintaining long-term memories in the brain. Atypical PKC (aPKC) isoforms [zeta (this enzyme) and lambda/iota] play important roles in insulin-stimulated glucose transport. Human adipocytes contain PKC-zeta, rather than PKC-lambda/iota, as their major aPKC. Inhibition of the PKCζ enzyme inhibits insulin-stimulated glucose transport while activation of PKCζ increases glucose transport.

Background References

1. Cao YJ et al. PKC-zeta Aggravates Doxorubicin-Induced Cardiotoxicity by Inhibiting Wnt/beta-Catenin Signaling. Front Pharmacol. 2022 Feb

2. Zhang F et al. PKC-zeta mediated reduction of the extracellular vesicles-associated TGF-beta1 overcomes radiotherapy resistance in breast cancer. Breast Cancer Res. 2023 Apr

Subcellular Location

Cytoplasm, Endosome, Cell junction, Membrane.

UNIPROT

SwissProt: Q05513 Human

Synonyms