CD24 Rabbit Polyclonal Antibody (R1303-1)

UNIPROT #

P25063

PROTEIN NAME

CD24

SYNONYMS

CD 24 antibody;CD24 antibody;CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody;CD24 antigen antibody;CD24 molecule antibody;CD24_HUMAN antibody;CD24A antibody;FLJ22950 antibody;FLJ43543 antibody;GPI linked surface mucin antibody;Heat stable antigen antibody;HSA antibody;MGC75043 antibody;Nectadrin antibody;Signal transducer CD24 antibody;Small cell lung carcinoma cluster 4 antigen antibody

SEQUENCE SIMILARITIES

Belongs to the CD24 family.

TISSUE SPECIFICITY

B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.

POST-TRANSLATIONAL MODIFICATION

Extensively O-glycosylated.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene. CD24 is a cell adhesion molecule. CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development. Cross-linking of CD24 on the surface of neutrophils induces apoptosis, and this appears to be defective in sepsis. CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222.