ATG12 Rabbit Polyclonal Antibody (R1404-1)

UNIPROT #

O94817

PROTEIN NAME

ATG12

SYNONYMS

APG12-like antibody;APG12L antibody;ATG12 antibody;ATG12 autophagy related 12 homolog (S. cerevisiae) antibody;ATG12 autophagy related 12 homolog antibody;ATG12_HUMAN antibody;Autophagy 12 antibody;Autophagy-related protein 12 antibody;FBR93 antibody;HAPG12 antibody;Ubiquitin-like protein ATG12 antibody

SEQUENCE SIMILARITIES

Belongs to the ATG12 family.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Acetylated by EP300.

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

Autophagy-related protein 12 is a protein that in humans is encoded by the ATG12 gene. Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy. Autophagy requires the covalent attachment of the protein Atg12 to ATG5 through a ubiquitin-like conjugation system. The Atg12-Atg5 conjugate then promotes the conjugation of ATG8 to the lipid phosphatidylethanolamine. Atg12 was found to be involved in apoptosis. This protein promotes apoptosis through an interaction with anti-apoptotic members of the Bcl-2 family.