IFNAR1 Rabbit Polyclonal Antibody (R1511-30)

UNIPROT #

P17181

PROTEIN NAME

IFNAR1

SYNONYMS

Alpha type antiviral protein antibody;Antiviral protein, alpha-type antibody;Antiviral protein, beta-type antibody;AVP antibody;Beta type antiviral protein antibody;CRF2-1 antibody;Cytokine receptor class-II member 1 antibody;Cytokine receptor family 2 member 1 antibody;IFN alpha REC antibody;IFN alpha receptor antibody;IFN alpha/beta Receptor alpha antibody;IFN beta receptor antibody;IFN Interferon-beta receptor antibody;IFN-alpha/beta receptor 1 antibody;IFN-R-1 antibody;IFNAR antibody;Ifnar1 antibody;IFNBR antibody;IFRC antibody;INAR1_HUMAN antibody;Interferon (alpha beta and omega) receptor 1 antibody;interferon alpha and beta receptor subunit 1 antibody;Interferon alpha/beta receptor 1 antibody;Interferon alpha/beta receptor alpha chain antibody;Interferon beta receptor 1 antibody;interferon receptor 1 antibody;Interferon-alpha receptor antibody;Type I interferon receptor 1 antibody

SEQUENCE SIMILARITIES

Belongs to the type II cytokine receptor family.

TISSUE SPECIFICITY

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated, leading to its internalization and degradation. Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex.; Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination. Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. Phosphorylated on tyrosine residues in response to interferon.; Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.

SUBCELLULAR LOCATION

Late endosome, Lysosome, Cell membrane.

FUNCTION

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.