TREM1 Rabbit Polyclonal Antibody

Function

Triggering receptor expressed on myeloid cells 1 is a protein that in humans is encoded by the TREM1 gene. Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1), Fc receptors (see MIM 146790), CD14 and Toll-like receptors (e.g., TLR4), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1). In granulocyte cells, TREM1 is activated by C/EBPε independently from inflammatory response. Model organisms have been used in the study of TREM1 function. A conditional knockout mouse line called Trem1tm1(KOMP)Vlcg was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping.

Background References

暂无

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Secreted (Potential).

UNIPROT

SwissProt: Q9NP99 Human

Synonyms

CD354 antibody

OTTMUSP00000018206 antibody

TREM 1 antibody

TREM-1 antibody

TREM1 antibody

TREM1_HUMAN antibody

Triggering receptor expressed on monocytes 1 antibody

Triggering receptor expressed on myeloid cells 1 antibody

Triggering receptor TREM 1 antibody

Triggering receptor TREM1 antibody