ABL2 Recombinant Rabbit Monoclonal Antibody [JF0951] (ET1702-07)

UNIPROT #

P42684

PROTEIN NAME

ABL2

SYNONYMS

Abelson murine leukemia viral oncogene homolog 2 antibody;Abelson related gene protein antibody;Abelson tyrosine-protein kinase 2 antibody;Abelson-related gene protein antibody;ABL2 antibody;ABL2_HUMAN antibody;ABLL antibody;ARG antibody;Tyrosine kinase ARG antibody;Tyrosine protein kinase ABL2 antibody;Tyrosine-protein kinase ARG antibody;v abl Abelson murine leukemia viral oncogene homolog 2 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity).; Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton.

FUNCTION

The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including chronic myelocytic leukemia (CML), in which it undergoes a (9;22) chromosomal translocation and produces the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein tyrosine kinase. The related protein tyrosine kinase Arg, also designated Abl2, contains an SH2 and an SH3 domain. Arg has been shown to interact with and to phosphorylate c-Crk.