alpha smooth muscle Actin Recombinant Rabbit Monoclonal Antibody [SY02-64]
Catalog# ET1607-53
alpha smooth muscle Actin Recombinant Rabbit Monoclonal Antibody [SY02-64]
-
WB
-
IF-Cell
-
IF-Tissue
-
IHC-P
-
FC
-
mIHC
-
Human
-
Mouse
-
Rat
-
HA750126
不含抗保成分
-
unconjugated
Overview
Product Name
alpha smooth muscle Actin Recombinant Rabbit Monoclonal Antibody [SY02-64]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Synthetic peptide within N-terminal human alpha smooth muscle Actin.
Species Reactivity
Human, Mouse, Rat
Validated Applications
WB, IF-Cell, IF-Tissue, IHC-P, FC, mIHC
Molecular Weight
Predicted band size: 42 kDa
Positive Control
Saos-2 (Human osteosarcoma cells) cell lysate, A431 (Human epidermoid carcinoma skin squamous cells) cell lysate, NIH/3T3 (Mouse fibroblasts) cell lysate, C2C12 (Mouse myoblasts) cell lysate, Neuro-2a (Mouse brain neuroblastoma cells) cell lysate, Mouse skin tissue lysate, Rat skin tissue lysate.
Conjugation
unconjugated
Clone Number
SY02-64
RRID
Reactivity Data
| WB | IF-Cell | IF-Tissue | IHC-P | FC | mIHC | |
|---|---|---|---|---|---|---|
| Human |
|
|
|
|
|
|
| Mouse |
|
|
|
|
|
|
| Rat |
|
|
|
|
|
|
| Ctenopharyngodon |
|
|||||
| Rabbit |
|
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
-
1:1,000-1:5,000
-
IF-Cell
-
1:2,000-1:5,000
-
IF-Tissue
-
1:50-1:200
-
IHC-P
-
1:1,000-1:5,000
-
FC
-
1:1,000-1:2,000
-
mIHC
-
1:100-1:500
Target
Function
All eukaryotic cells express Actin, which often constitutes as much as 50% of total cellular protein. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. While lower eukaryotes, such as yeast, have only one Actin gene, higher eukaryotes have several isoforms encoded by a family of genes. At least six types of Actin are present in mammalian tissues and fall into three classes. α-Actin expression is limited to various types of muscle, whereas β-Actin and γ-Actin are the principle constituents of filaments in other tissues. Members of the small GTPase family regulate the organization of the Actin cytoskeleton. Rho controls the assembly of Actin stress fibers and focal adhesion. Rac regulates Actin filament accumulation at the plasma membrane. Cdc42 stimulates formation of filopodia.
Background References
1. Izumi D et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin 1 clustering and invasiveness in gastric cancer. Int J Cancer 138:1207-19 (2016).
2. Chung SI et al. Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. BMC Gastroenterol 16:13 (2016).
Sequence Similarity
Belongs to the actin family.
Post-translational Modification
Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.; Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.; Methylated at His-75 by SETD3.; (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding. The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners.
Subcellular Location
Cytoplasm.
Synonyms
alpha SMA
a-SMA antibody
asma antibody
a actin antibody
AAT6 antibody
ACTA_HUMAN antibody
ACTA2 antibody
Actin alpha 2 smooth muscle aorta antibody
Actin aortic smooth muscle antibody
Actin, aortic smooth muscle antibody
ExpandImages
-
Application: IF-tissue
Species: Human
Site: Kidney
Sample: Paraffin-embedded section
Antibody concentration: 1/50 -
-
Application: IF-tissue
Species: Mouse
Site: Liver
Sample: Paraffin-embedded section
Antibody concentration: 1/50 -
Fluorescence multiplex immunohistochemical analysis of the human pancreatic carcinoma (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-CD31 (M1511-8, green), anti-α-SMA (ET1607-53, red) and anti-FAP (ET1704-23, yellow) on human pancreatic carcinoma. Panel B: anti- CD31 stained on the endothelial cells. Panel C: anti-α-SMA stained on cancer-associated fibroblasts and smooth muscle cells. Panel D: anti-FAP stained on the cancer-associated fibroblasts. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in three rounds of staining: in the order of M1511-8 (1/5000 dilution), ET1704-23 (1/1000 dilution), and ET1607-53 (1/150 dilution) for 20 mins at room temperature. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Nikon ECLIPSE Ni-E microscope.
-
Fluorescence multiplex immunohistochemical analysis of Human non-small cell lung cancer (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-PD-L1 (HA721176, red), anti-CD34 (ET1606-11, green), anti-Pan-CK (HA601138, cyan), anti-CD20 (HA721138, magenta), anti-αSMA (ET1607-53, yellow) and anti-CD57 (HA601114, white) on NSCLC. Panel B: anti-PD-L1 stained on dendritic cells and macrophages cells. Panel C: anti- CD34 stained on endothelial cells. Panel D: anti-Pan-CK stained on cancer cells. Panel E: CD20 stained on B cells. Panel F: anti-αSMA stained on cancer-associated fibroblasts and smooth muscle cells. Panel G: anti-CD57 stained on NK cells and T cells. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in six rounds of staining: in the order of HA721176 (1/1,000 dilution), ET1606-11 (1/1,000 dilution), HA601138 (1/3,000 dilution), HA721138 (1/2,000 dilution), ET1607-53 (1/150 dilution) and HA601114 (1/1,000 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
-
Fluorescence multiplex immunohistochemical analysis of the human gastric cancer (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-CD31 (M1511-8, red), anti-αSMA (ET1607-53, gray), anti-CD11b (ET1706-04, cyan), anti-panCK (HA601138, magenta) and anti-CD3 (HA720082, yellow) on human gastric cancer. Panel B: anti- CD31 stained on the endothelial cells. Panel C: anti-αSMA stained on cancer-associated fibroblasts and smooth muscle cells. Panel D: anti-CD11b stained on myeloid cells. Panel E: anti-panCK stained on cancer cells. Panel F: anti-CD3 stained on T cells. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in five rounds of staining: in the order of M1511-8 (1/1,000 dilution), ET1607-53 (1/100 dilution), ET1706-04 (1/1,000 dilution), HA601138 (1/3,000 dilution), and HA720082 (1/500 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
-
Fluorescence multiplex immunohistochemical analysis of mouse lung (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-TTF1 (HA720067, Red), anti-RAGE (ET1702-27, Green), anti-aSMA (ET1607-53, Cyan) and anti-Ki67 (HA721115, Yellow) on mouse lung. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in four rounds of staining: in the order of HA720067 (1/4,000 dilution), ET1702-27 (1/3,000 dilution), ET1607-53 (1/500 dilution) and HA721115 (1/3,000 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
-
Fluorescence multiplex immunohistochemical analysis of the human gastric cancer (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-Ki67 (HA721115, red), anti-CD31 (M1511-8, green), anti-CD3 (HA720082, cyan), anti-panCK (HA601138, magenta) and anti-αSMA (ET1607-53, yellow) on human gastric cancer. Panel B: anti- Ki67 stained on cells in G1, S, G2 and M phases of cell cycle. Panel C: anti-CD31 stained on the endothelial cells. Panel D: anti-CD3 stained on T cells. Panel E: anti-panCK stained on cancer cells. Panel F: anti-αSMA stained on cancer-associated fibroblasts and smooth muscle cells. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in five rounds of staining: in the order of HA721115 (1/2,000 dilution), M1511-8 (1/1,000 dilution), HA720082 (1/500 dilution), HA601138 (1/3,000 dilution), and ET1607-53 (1/100 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
-
Fluorescence multiplex immunohistochemical analysis of human liver (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-CD31(M1511-8, Red), anti-COL1A1(HA722517, Magenta) and anti-αSMA (ET1607-53, Yellow) on human liver. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in three rounds of staining: in the order of M1511-8 (1/1000 dilution), HA722517 (1/10000 dilution) and ET1607-53 (1/250 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95C. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
-
Fluorescence multiplex immunohistochemical analysis of mouse pancreas (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-β-catenin (ET1601-5, Red), anti-Glucagon (ET1702-20, Green), anti-Insulin (ET1601-12, White), anti-CK19 (ET1601-6, Magenta) and anti-aSMA (ET1607-53, Yellow) on mouse pancreas. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in five rounds of staining: in the order of ET1601-5 (1/2,000 dilution), ET1702-20 (1/6,000 dilution), ET1601-12 (1/8,000 dilution), ET1601-6 (1/5,000 dilution) and ET1607-53 (1/500 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
-
Fluorescence multiplex immunohistochemical analysis of mouse liver (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-HNF4α (HA721006, Cyan), anti-CK19 (ET1601-6, Magenta) and anti-aSMA (ET1607-53, Yellow) on mouse liver. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in three rounds of staining: in the order of HA721006 (1/5,000 dilution), ET1601-6 (1/10,000 dilution) and ET1607-53 (1/500 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
-
Fluorescence multiplex immunohistochemical analysis of mouse small intestine (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-Lysozyme (ET1609-35, Green), anti-villin1 (ET7106-62, Magenta) and anti-aSMA (ET1607-53, Yellow) on mouse small intestine. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in three rounds of staining: in the order of ET1609-35 (1/2,000 dilution), ET7106-62 (1/5,000 dilution) and ET1607-53 (1/500 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
-
Fluorescence multiplex immunohistochemical analysis of mouse kidney (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-NPHS2 (ET7107-34, Red), anti-AQP1 (ET1703-34, Green), anti-Laminin beta 1 (ET1703-14, Cyan) and anti-aSMA (ET1607-53, Magenta) on kidney. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in four rounds of staining: in the order of ET7107-34 (1/1,000 dilution), ET1703-34 (1/5,000 dilution), ET1703-14 (1/1,000 dilution) and ET1607-53 (1/500 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
-
Western blot analysis of alpha smooth muscle Actin on different lysates with Rabbit anti-alpha smooth muscle Actin antibody (ET1607-53) at 1/2,000 dilution.
Lane 1: Saos-2 (Human osteosarcoma cells) cell lysate
Lane 2: A431 (Human epidermoid carcinoma skin squamous cells) cell lysate
Lane 3: NIH/3T3 (Mouse fibroblasts) cell lysate
Lane 4: C2C12 (Mouse myoblasts) cell lysate
Lane 5: Neuro-2a (Mouse brain neuroblastoma cells) cell lysate
Lane 6: Mouse skin tissue lysate
Lane 7: Rat skin tissue lysate
Lysates/proteins at 15 µg/Lane.
Exposure time: 2 seconds; ECL: K1801
Blocking: 5% NFDM/TBST, 1 hour at room temperature
Primary antibody: ET1607-53, 1/2,000 in primary antibody dilution buffer (K1803), overnight at 4 ℃
Secondary antibody: Goat anti-Rabbit IgG-HRP (HA1001), 1/50,000 in 5% NFDM/TBST, 1 hour at room temperature
Predicted band size: 42 kDa
Observed band size: 42 kDa -
Application: Immunocytochemistry (IF-cell)
Species: Human
Sample: Hep G2 (Human liver cancer cells)
Fixation: 4% Paraformaldehyde, 15 minutes at room temperature.
Permeabilization: 0.1% Triton X-100, 15 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 1 hour at room temperature.
Antibody dilution buffer: 1% BSA in PBST.
Primary antibody: ET1607-53, 1/2,000, overnight at 4℃.
Secondary antibody: Goat Anti-Rabbit IgG (iFluor™ 488, HA1121), 45 minutes at room temperature.
Counterstain: Beta tubulin (HA601187, red), 1/100, overnight at 4℃. The Nuclear counterstain was DAPI (Blue). -
Application: Immunohistochemistry (IHC-P)
Species: Human
Tissue: Breast carcinoma
Sample: Paraffin-embedded section
Antigen retrieval: Heat-mediated, Tris-EDTA buffer (pH 9.0), 20 minutes at 95℃.
Wash buffer: 1× TBST
Endogenous peroxidase blocking: 3% H₂O₂, 10 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 10 minutes at room temperature.
Primary antibody: ET1607-53, 1/1,000, 1 hour at room temperature.
Secondary antibody: HA1119, 20 minutes at room temperature. -
Application: Immunohistochemistry (IHC-P)
Species: Mouse
Tissue: Small intestine
Sample: Paraffin-embedded section
Antigen retrieval: Heat-mediated, Tris-EDTA buffer (pH 9.0), 20 minutes at 95℃.
Wash buffer: 1× TBST
Endogenous peroxidase blocking: 3% H₂O₂, 10 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 10 minutes at room temperature.
Primary antibody: ET1607-53, 1/1,000, 1 hour at room temperature.
Secondary antibody: HA1119, 20 minutes at room temperature. -
Application: Immunohistochemistry (IHC-P)
Species: Rat
Tissue: Small intestine
Sample: Paraffin-embedded section
Antigen retrieval: Heat-mediated, Tris-EDTA buffer (pH 9.0), 20 minutes at 95℃.
Wash buffer: 1× TBST
Endogenous peroxidase blocking: 3% H₂O₂, 10 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 10 minutes at room temperature.
Primary antibody: ET1607-53, 1/1,000, 1 hour at room temperature.
Secondary antibody: HA1119, 20 minutes at room temperature. -
Application: Flow Cytometry (Intra)
Species: Human
Sample: Hep G2 (Human liver cancer cells)
Fixation: 4% Paraformaldehyde, 15 minutes at room temperature.
Permeabilization: 1x Permeabilization Buffer (eBioscience), 15 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 15 minutes at room temperature.
Antibody dilution buffer: 1x PBS.
Primary antibody: ET1607-53 (1/1,000) (Red) compared with Rabbit IgG Isotype Control (HA722127, Green), 15 minutes at room temperature.
Secondary antibody: Goat Anti-Rabbit IgG (iFluor™ 488, HA1121), 15 minutes at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Citation
-
Molecular mechanisms of DBDPE-induced spermatogenic disorder: A network toxicology, machine learning, and in vivo experimental validation
Journal: Environment International
DOI: 10.1016/j.envint.2026.110220
IF: 9.7
Application: WB
Reactivity: Mouse
Publish date: 2026 Mar
-
Multi-omics causal inference unravels arterial BCAR1 as a novel protective factor against intracranial aneurysm
Journal: International Journal of Surgery
DOI: 10.1097/JS9.0000000000005004
IF: 10.1
Application: mIF
Reactivity: Human
Publish date: 2026 Mar
-
Discovery and validation of a urinary extracellular vesicle protein signature for the diagnosis of renal allograft fibrosis
Journal: Interdisciplinary Medicine
DOI: 10.1002/inmd.70108
IF: 13.6
Application: WB
Reactivity: Mouse
Publish date: 2026 Mar
-
Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis
Journal: Cell
DOI: 10.1016/j.cell.2026.02.001
IF: 42.5
Application: mIF
Reactivity: Mouse
Publish date: 2026 Mar
-
Metallothionein Safeguards Hepatic Zn-Fe Homeostasis and Restrains Yap-Driven Hepatic Fe Overload to Protect Against Chronic Liver Fibrosis
Journal: Liver International
DOI: 10.1111/liv.70624
IF: 5.2
Application: IF-tissue,WB
Reactivity: Mouse
Publish date: 2026 Mar
-
Shengxian Decoction mitigate bleomycin-induced pulmonary fibrosis in mice via MerTK mediated macrophage efferocytosis
Journal: Journal Of Ethnopharmacology
DOI: 10.1016/j.jep.2026.121583
IF: 5.4
Application: WB,IF-tissue
Reactivity: Mouse
Publish date: 2026 Mar
-
Effect of chronic intermittent hypoxia on apoptosis based on microbiome-based co-metabolomics
Journal: Experimental Neurology
DOI: 10.1016/j.expneurol.2026.115726
IF: 4.2
Application: WB
Reactivity: Mouse
Publish date: 2026 Mar
-
Vitamin B12 attenuates post-ischemic brain fibrotic remodeling and suppresses MAPK1 signaling in male rats
Journal: Brain Research Bulletin
DOI: 10.1016/j.brainresbull.2026.111847
IF: 3.7
Application: WB
Reactivity: Rat
Publish date: 2026 Mar
-
Unraveling the therapeutic mechanisms of Polygonum cuspidatum in pulmonary fibrosis: Modulation of M2 macrophage polarization and glycolysis pathways
Journal: Journal Of Ethnopharmacology
DOI: 10.1016/j.jep.2026.121461
IF: 5.4
Application: IF-cell
Reactivity: Human
Publish date: 2026 Mar
-
PTPN2 alleviates Silicotic pulmonary fibrosis by inhibiting senescence of type II alveolar epithelial cells via retinol metabolism regulated by ALDH1A2
Journal: International Immunopharmacology
DOI: 10.1016/j.intimp.2026.116226
IF: 4.7
Application: WB
Reactivity: Mouse
Publish date: 2026 Jan
-
Suppressing Endothelial–Mesenchymal Transition Through the Histone Deacetylase 1/GATA Binding Protein 4 Pathway: The Mechanism of Protocatechuic Acid Against Myocardial Fibrosis Revealed by an Integrated Study
Journal: Biology-Basel
DOI: 10.3390/biology15020206
IF: 3.5
Application: IHC
Reactivity: Rat
Publish date: 2026 Jan
-
<p>Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway</p>
Journal: International Journal Of Molecular Medicine
DOI: 10.3892/ijmm.2026.5740
IF: 5.8
Application: IHC
Reactivity: Mouse
Publish date: 2026 Jan
-
Macrophage-associated immune-stromal crosstalks correlate with the tumor microenvironment in microsatellite-stable mucinous colorectal cancer
Journal: Pathology Research and Practice
DOI: 10.1016/j.prp.2026.156371
IF: 3.2
Application: mIF
Reactivity: Human
Publish date: 2026 Jan
-
Apoptotic Vesicle Membrane-Mediated Targeted Endothelial Mitochondrial Transplantation-Clearance Therapy for Diabetic Wound Healing
Journal: Research
DOI: 10.34133/research.1042
IF: 10.7
Application: IF-tissue
Reactivity: Rat
Publish date: 2026 Jan
-
SPP1 Drives Colorectal Cancer Liver Metastasis and Immunotherapy Resistance by Stimulating CXCL12 Production in Cancer-Associated Fibroblasts
Journal: Cancer Research
DOI: 10.1158/0008-5472.CAN-24-4916
IF: 16.6
Application: IHC,mIF
Reactivity: Human,Mouse
Publish date: 2026 Jan
-
SCMO: a deep learning model integrating the single-cell resolution TME ecosystem and multi-omics for survival prediction in CRC patients
Journal: Journal Of Translational Medicine
DOI: 10.1186/s12967-025-07417-y
IF: 7.5
Application: WB
Reactivity: Human
Publish date: 2026 Feb
-
Mitofusin 2 Alleviates Liver Fibrogenesis by Suppressing β-Catenin Nuclear Translocation
Journal: Current Medical Science
DOI: 10.1007/s11596-026-00167-y
IF: 1.5
Application: WB
Reactivity: Mouse
Publish date: 2026 Feb
-
Triptolide Inhibits Renal Fibrosis Through Promotion of PGC1α/PCK1-mediated Renal Gluconeogenesis
Journal: Frontiers In Bioscience-Landmark
DOI: 10.31083/FBL47847
IF: 3.1
Application: WB
Reactivity: Mouse
Publish date: 2026 Feb
-
Serpine1 Regulates the Enhanced Inhibitory Effect of CHIR99021 Combined with Fibroblast Growth Factor 2 on Myocardial Fibrosis After Myocardial Infarction in Mice
Journal: International Journal Of Molecular Sciences
DOI: 10.3390/ijms27041627
IF: 4.9
Application: IF-tissue,WB
Reactivity: Rat
Publish date: 2026 Feb
-
Genipin, A Gut Microbiota-Derived Metabolite of Xihuang Pill, Suppresses Triple-Negative Breast Cancer Angiogenesis by Inhibiting HIF-1α/HSPG2 Axis
Journal: Phytotherapy Research
DOI: 10.1002/ptr.70253
IF: 6.3
Application: IF-tissue
Reactivity: Mouse
Publish date: 2026 Feb
-
Design, Synthesis, and Biological Evaluation of Arylimidazole Derivatives as Potent PPARδ Agonists for the Treatment of Renal Fibrosis
Journal: Journal Of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5c03132
IF: 6.8
Application: WB
Reactivity: Rat,Mouse
Publish date: 2026 Feb
-
Berberine inhibits ISG15 and pyroptosis to attenuate diabetic kidney disease inflammation and fibrosis
Journal: Apoptosis
DOI: 10.1007/s10495-026-02282-6
IF: 8.1
Application: WB
Reactivity: Mouse
Publish date: 2026 Feb
-
Shenkangling alleviates renal fibrosis induced by renal ischemia–reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway
Journal: Phytomedicine
DOI: 10.1016/j.phymed.2026.158020
IF: 8.3
Application: WB
Reactivity: Human,Mouse
Publish date: 2026 Feb
-
TAT-PBX1 fusion protein alleviates LPS-induced acute lung injury via AMPK-TFAM signaling activation
Journal: Molecular Therapy
DOI: 10.1016/j.ymthe.2025.09.010
IF: 12
Application: IHC
Reactivity: Mouse
Publish date: 2025 Sept
-
Interleukin-17D Attenuates OVA-induced Airway Inflammation and Remodeling Partially via the CD93 Receptor
Journal: Allergy Asthma & Immunology Research
DOI: 10.4168/aair.2025.17.5.592
IF: 4.3
Application: WB
Reactivity:
Publish date: 2025 Sept
-
MIF Promotes Phenotypic Switching of VSMCs via AKT/mTOR-Mediated Autophagy Regulation in Aortic Dissection
Journal: FASEB Journal
DOI: 10.1096/fj.202501761R
IF: 4.2
Application: IF-cell
Reactivity: Human
Publish date: 2025 Sept
-
Deficiency of Vitamin D-binding protein exacerbates liver fibrosis by disrupting iron homeostasis via the activation of YAP signaling
Journal: Experimental Cell Research
DOI: 10.1016/j.yexcr.2025.114767
IF: 3.5
Application: WB
Reactivity: Mouse
Publish date: 2025 Sept
-
Astragaloside IV Binds with RhoA, Inhibits EndMT and Ameliorates Myocardial Fibrosis in Mice
Journal: American Journal Of Chinese Medicine
DOI: 10.1142/S0192415X25500818
IF: 5.5
Application: WB
Reactivity: Mouse,Human
Publish date: 2025 Sept
-
Metformin attenuates coal dust nanoparticle-induced pulmonary fibrosis by modulating inflammation and epithelial-mesenchymal transition
Journal: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115497
IF: 4.7
Application: WB,IHC
Reactivity: Mouse,Human
Publish date: 2025 Sept
-
Brain abundant membrane attached signal protein 1 regulates macrophage polarization through EGFR/PI3K/AKT signaling in renal cell carcinoma
Journal: International Journal Of Biological Macromolecules
DOI: 10.1016/j.ijbiomac.2025.148268
IF: 8.5
Application: IHC
Reactivity: Mouse
Publish date: 2025 Oct
-
Immune landscape and molecular regulators in renal interstitial fibrosis
Journal: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115702
IF: 4.7
Application: WB
Reactivity: Mouse
Publish date: 2025 Oct
-
Fennel essential oil and its nanoemulsion modulate macrophage-mediated inflammatory responses and promote pressure ulcer healing
Journal: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115631
IF: 4.7
Application: IF-cell
Reactivity: Rat
Publish date: 2025 Oct
-
High PEEP Activates ITGB1, Inducing Diaphragm Fibrosis During Prolonged Mechanical Ventilation
Journal: Biomolecules
DOI: 10.3390/biom15101466
IF: 4.8
Application: WB
Reactivity: Rabbit
Publish date: 2025 Oct
-
Mechanistic study on nonylphenol-induced liver fibrosis via Pink1/Parkin-mediated mitophagy and lipid droplet degradation in hepatic stellate cells
Journal: Ecotoxicology And Environmental Safety
DOI: 10.1016/j.ecoenv.2025.119206
IF: 6.1
Application: WB,IF-tissue
Reactivity: Mouse,Human
Publish date: 2025 Oct
-
Genome editing of Spp1 by inhalable CRISPR/Cas9 formulation for treating pulmonary fibrosis
Journal: Journal Of Controlled Release
DOI: 10.1016/j.jconrel.2025.114424
IF: 11.5
Application:
Reactivity:
Publish date: 2025 Nov
-
Targeting renal tubular WWP2 to restore mitochondrial OXPHOS integrity retards the AKI-to-CKD transition
Journal: Molecular Therapy
DOI: 10.1016/j.ymthe.2025.11.022
IF: 12
Application: WB
Reactivity: Mouse
Publish date: 2025 Nov
-
Ganetespib as an inhibitor of heat shock protein 90 alleviates pulmonary fibrosis by inhibiting the Wnt/β-catenin signaling pathway
Journal: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115837
IF: 4.7
Application: WB
Reactivity: Mouse
Publish date: 2025 Nov
-
Schisandra chinensis-Derived Bioactive Constituents Loaded in pH-ROS Dual-Responsive Polysaccharide Nanoparticles for Atherosclerosis Treatment
Journal: Phytomedicine
DOI: 10.1016/j.phymed.2025.157536
IF: 8.3
Application: IF-tissue
Reactivity: Mouse
Publish date: 2025 Nov
-
Enhanced oral nanomedicine utilizing biomineralized oncolytic virus for synergistic gastrointestinal cancer therapy
Journal: Materials Today Bio
DOI: 10.1016/j.mtbio.2025.102583
IF: 10.2
Application: WB,IHC
Reactivity: Mouse
Publish date: 2025 Nov
-
A Novel Long-Term Intrathecal Cannulation Technique in Rats: L5-L6 Approach With Cervical Externalization for Chronic Drug Delivery
Journal: Journal Of Integrative Neuroscience
DOI: 10.31083/JIN45111
IF: 2.7
Application: WB
Reactivity: Rat
Publish date: 2025 Nov
-
Podocyte FFAR4 deficiency aggravated glomerular diseases and aging
Journal: Molecular Therapy
DOI: 10.1016/j.ymthe.2025.05.035
IF: 12.1
Application: IHC,WB
Reactivity: Mouse
Publish date: 2025 May
-
Therapeutic potential of voltage-dependent potassium channel subtype 1.3 blockade in alleviating macrophage-related renal inflammation and fibrogenesis
Journal: Cell Death Discovery
DOI: 10.1038/s41420-025-02508-7
IF: 6.1
Application: WB
Reactivity: Mouse,Human
Publish date: 2025 May
-
Discrepancies between human and murine model cerebral aneurysms at single-cell resolution
Journal: Frontiers In Cell And Developmental Biology
DOI: 10.3389/fcell.2025.1512938
IF: 4.6
Application: mIHC
Reactivity: Human
Publish date: 2025 Mar
-
Chondroitin Sulfate-Based Imatinib Nanoparticles Targeting Activated Hepatic Stellate Cells Against Hepatic Fibrosis
Journal: Pharmaceutics
DOI: 10.3390/pharmaceutics17030351
IF: 4.9
Application: WB
Reactivity: Rat
Publish date: 2025 Mar
-
Ultrasound-Driven Piezoelectric Heterostructures Block Early Atherosclerotic Plaques Progression
Journal: Small
DOI: 10.1002/smll.202412815
IF: 12.1
Application: IF-Tissue
Reactivity: Mouse
Publish date: 2025 Mar
-
Vaccarin Ameliorates Renal Fibrosis by Inhibiting Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway
Journal: Drug Design Development And Therapy
DOI: 10.2147/DDDT.S509357
IF: 4.7
Application: WB
Reactivity: Mouse
Publish date: 2025 Mar
-
Preclinical and clinical evaluation of intratumoral injection of an IL-12 expressing SKV-012 oncolytic virus for advanced solid tumors
Journal: Journal For Immunotherapy Of Cancer
DOI: 10.1136/jitc-2025-011642
IF: 10.6
Application: mIHC
Reactivity: Mouse
Publish date: 2025 Jun
-
Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3
Journal: Science Advances
DOI: 10.1126/sciadv.adu8422
IF: 12.5
Application:
Reactivity:
Publish date: 2025 Jun
-
Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling
Journal: European Journal of Histochemistry
DOI: 10.4081/ejh.2025.4218
IF: 2.1
Application: WB
Reactivity: Human
Publish date: 2025 Jun
-
Pachymic acid alleviates secondary lymphedema through the modulation of EETs level and the inhibition of lymphatic fibrosis
Journal: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115066
IF: 4.7
Application: IHC,WB
Reactivity: Mouse,Human
Publish date: 2025 Jun
-
Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway
Journal: American Journal Of Physiology-Cell Physiology
DOI: 10.1152/ajpcell.01006.2024
IF: 4.7
Application: WB
Reactivity: Mouse,Rat
Publish date: 2025 Jun
-
PKM2 Drives Lactate-mediated Fibrosis in Liver Transplantation
Journal: Transplantation
DOI: 10.1097/TP.0000000000005461
IF: 5
Application: IHC,FC,WB
Reactivity: Mouse
Publish date: 2025 Jun
-
Asiatic Acid Inhibits Keloid Fibroblast Migration and Collagen Deposition via Suppression of STAT3 Activation
Journal: Burns
DOI: 10.1016/j.burns.2025.107586
IF: 2.9
Application: WB
Reactivity: Human
Publish date: 2025 Jun
-
Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation
Journal: Journal Of Translational Medicine
DOI: 10.1186/s12967-025-06880-x
IF: 7.5
Application: IHC
Reactivity: Mouse,Human
Publish date: 2025 Jul
-
Therapeutic Potential of PDA@CeO2 in Suppressing Hepatic Stellate Cell Activation and Preventing Liver Fibrosis
Journal: International Journal Of Nanomedicine
DOI: 10.2147/IJN.S521372
IF: 6.5
Application: IHC,WB
Reactivity: Rat
Publish date: 2025 Jul
-
aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound
Journal: Journal Of Nanobiotechnology
DOI:
IF: 10.6
Application: IF-cell
Reactivity: Mouse
Publish date: 2025 Jan
-
Inhalable Chemotactic Liposome for Targeted Modulation of Pulmonary Pre-Metastatic Niche
Journal: Advanced Functional Materials
DOI: 10.1002/adfm.202419583
IF: 19
Application: IF-Tissue
Reactivity: Mouse
Publish date: 2025 Jan
-
Inhibiting autophagy selectively prunes dysfunctional tumor vessels and optimizes the tumor immune microenvironment
Journal: Theranostics
DOI:
IF: 12.4
Application: mIHC
Reactivity: Mouse
Publish date: 2025 Jan
-
Hypoxia-inducible factor-1α inhibitor promotes non-alcoholic steatohepatitis development and increases hepatocellular lipid accumulation via TSKU upregulation
Journal: Archives Of Biochemistry And Biophysics
DOI:
IF: 3.8
Application: WB
Reactivity: Mouse
Publish date: 2025 Jan
-
Inhibiting autophagy selectively prunes dysfunctional tumor vessels and optimizes the tumor immune microenvironment
Journal: Theranostics
DOI: 10.7150/thno.98285
IF: 13.3
Application: mIHC
Reactivity: Mouse
Publish date: 2025 Jan
-
Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction
Journal: Frontiers in Immunology
DOI: 10.3389/fimmu.2024.1484234
IF: 5.9
Application: IF-Tissue
Reactivity: Human
Publish date: 2025 Jan
-
Activation of the WNT4/ β-catenin/FOXO1 pathway by PDK1 promotes cervical cancer metastasis and EMT process
Journal: JOURNAL OF MOLECULAR HISTOLOGY
DOI: 10.1007/s10735-024-10342-x
IF: 2.2
Application: WB
Reactivity: Human
Publish date: 2025 Jan
-
Liver-Secreted Extracellular Vesicles Promote Cirrhosis-Associated Skeletal Muscle Injury Through mtDNA-cGAS/STING Axis
Journal: Advanced Science
DOI: 10.1002/advs.202410439
IF: 14.1
Application: WB
Reactivity: Mouse
Publish date: 2025 Jan
-
Hypoxia-inducible factor-1α inhibitor promotes non-alcoholic steatohepatitis development and increases hepatocellular lipid accumulation via TSKU upregulation
Journal: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
DOI: 10.1016/j.abb.2025.110313
IF: 3
Application: WB
Reactivity: Mouse
Publish date: 2025 Jan
-
aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound
Journal: JOURNAL OF NANOBIOTECHNOLOGY
DOI: 10.1186/s12951-025-03105-7
IF: 12.6
Application: IF-Tissue
Reactivity: Mouse
Publish date: 2025 Jan
-
Single-cell transcriptomic profiling of rat iridocorneal angle at perinatal stages: Revisiting the development of periocular mesenchyme
Journal: Experimental Eye Research
DOI:
IF: 3
Application: IF-cell
Reactivity: Rat
Publish date: 2025 Jan
-
Magnetic Nanoactuator-Protein Fiber Coated Hydrogel Dressing for Well-Balanced Skin Wound Healing and Tissue Regeneration
Journal: ACS Applied Nano Materials
DOI:
IF: 15.8
Application: WB
Reactivity: Mouse,Human
Publish date: 2025 Jan
-
Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction
Journal: Frontiers In Immunology
DOI:
IF: 5.7
Application: IF-cell
Reactivity: Human
Publish date: 2025 Jan
-
Distinct maturity and spatial distribution of tertiary lymphoid structures in head and neck squamous cell carcinoma: implications for tumor immunity and clinical outcomes
Journal: Cancer Immunology Immunotherapy
DOI: 10.1007/s00262-025-03952-1
IF: 4.6
Application: mIHC
Reactivity: Human
Publish date: 2025 Feb
-
Safety, Efficacy and Bio-Distribution Analysis of Exosomes Derived From Human Umbilical Cord Mesenchymal Stem Cells for Effective Treatment of Bronchopulmonary Dysplasia by Intranasal Administration in Mice Model
Journal: International Journal Of Nanomedicine
DOI: 10.2147/IJN.S501843
IF: 6.6
Application: IHC-P
Reactivity: Mouse
Publish date: 2025 Feb
-
StatGel: An Innovative hydrogel carrying STAT3-targeted small molecule inhibitor for the treatment of abdominal adhesions
Journal: International Journal Of Pharmaceutics
DOI: 10.1016/j.ijpharm.2025.125320
IF: 5.3
Application: IEM,WB
Reactivity: Mouse
Publish date: 2025 Feb
-
FBXW7 mediates high glucose-induced epithelial to mesenchymal transition via KLF5 in renal tubular cells of diabetic kidney disease
Journal: Tissue & Cell
DOI: 10.1016/j.tice.2025.102801
IF: 2.7
Application: WB
Reactivity: Human
Publish date: 2025 Feb
-
Vitamin D alleviates diabetic kidney damage via TREM2-dependent modulation of ferritinophagy and macrophage polarization
Journal: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.116076
IF: 4.7
Application: WB
Reactivity: Rat
Publish date: 2025 Dec
-
Yanghe Pingchuan granules inhibit cellular senescence in airway smooth muscle cells to improve bronchial asthma via modulating Nrf2 acetylation
Journal: Respiratory Research
DOI: 10.1186/s12931-025-03345-z
IF: 5
Application: IF-cell
Reactivity: Rat
Publish date: 2025 Aug
-
Hesperetin alleviates liver fibrosis by improving intestinal microbiota composition and regulating hepatic stellate cell autophagy
Journal: European Journal Of Pharmacology
DOI: 10.1016/j.ejphar.2025.178106
IF: 4.7
Application: WB,IHC
Reactivity: Mouse,Human
Publish date: 2025 Aug
-
Rutaecarpine Alleviates Liver Fibrosis by Modulating the TRPV1/Connexin 43 Axis: A Study Based on Transcriptome Data, Single-cell Sequencing Data, and Cell Experiments
Journal: Biochemical And Biophysical Research Communications
DOI: 10.1016/j.bbrc.2025.152506
IF: 2.2
Application: WB
Reactivity: Human
Publish date: 2025 Aug
-
Ferroptosis and Low-Grade Glioma: The Breakthrough Potential of NUAK2
Journal: Free Radical Biology And Medicine
DOI: 10.1016/j.freeradbiomed.2025.04.035
IF: 7.1
Application: WB
Reactivity: Human
Publish date: 2025 Apr
-
Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway
Journal: Frontiers In Pharmacology
DOI: 10.3389/fphar.2025.1551141
IF: 4.4
Application: WB,IHC-P
Reactivity: Mouse
Publish date: 2025 Apr
-
Albiflorin inhibits inflammation to improve liver fibrosis by targeting the CXCL12/CXCR4 axis in mice
Journal: Frontiers In Pharmacology
DOI: 10.3389/fphar.2025.1577201
IF: 4.4
Application: WB
Reactivity: Mouse
Publish date: 2025 Apr
-
Integrated bioinformatics analysis screened the key genes and pathways of idiopathic pulmonary fibrosis
Journal: Scientific Reports
DOI: 10.1038/s41598-025-97037-9
IF: 3.8
Application: WB
Reactivity: Human
Publish date: 2025 Apr
-
Renal tubular epithelial cell-derived Exosomal miR-330-3p plays a key role in fibroblast activation and renal fibrosis by regulating CREBBP
Journal: Stem Cell Research & Therapy
DOI: 10.1186/s13287-025-04338-x
IF: 7.1
Application: IF-tissue
Reactivity: Mouse
Publish date: 2025 Apr
-
Unconjugated bilirubin promotes uric acid restoration by activating hepatic AMPK pathway
Journal: Free Radical Biology And Medicine
DOI: 10.1016/j.freeradbiomed.2024.09.023
IF: 7.1
Application: WB
Reactivity: Mouse
Publish date: 2024 Sept
-
A New Rat Model of Sacral Cord Injury Producing a Neurogenic Bladder and Its Functional and Mechanistic Studies
Journal: Biomolecules
DOI:
IF: 4.8
Application: WB
Reactivity: Rat
Publish date: 2024 Sep
-
Tanshinone IIA alleviates liver fibrosis through inducing inactivation and ferroptosis in hepatic stellate cells
Journal: Research Square
DOI:
IF:
Application: WB
Reactivity: Human
Publish date: 2024 Nov
-
Transcriptomics of tissue exosomes to investigate miR-195-5p's amelioration of endometrial fibrosis via the YAP-Smad7 pathway: an animal study
Journal: Journal Of Translational Medicine
DOI:
IF: 6.1
Application: IF-cell
Reactivity: Rat
Publish date: 2024 Nov
-
Nanomaterial‐Mediated Reprogramming of Macrophages to Inhibit Refractory Muscle Fibrosis
Journal: Advanced Materials
DOI:
IF: 27.4
Application: IF-cell
Reactivity: Mouse
Publish date: 2024 Nov
-
Gut commensal Parabacteroides distasonis exerts neuroprotective effects in acute ischemic stroke with hyperuricemia via regulating gut microbiota-gut-brain axis
Journal: Journal Of Translational Medicine
DOI:
IF: 6.1
Application: WB
Reactivity: Rat
Publish date: 2024 Nov
-
Furin knockdown inhibited EndMT and abnormal proliferation and migration of endothelial cells
Journal: Clinical Hemorheology And Microcirculation
DOI: 10.3233/CH-242171
IF: 2.1
Application: WB
Reactivity: Human
Publish date: 2024 May
-
Cell surface patching via CXCR4-targeted nanothreads for cancer metastasis inhibition
Journal: Nature Communications
DOI:
IF: 16.6
Application: FC
Reactivity: Mouse
Publish date: 2024 Mar
-
Low-intensity pulsed ultrasound combined with ST36 modulate gastric smooth muscle contractile marker expression via RhoA/Rock and MALAT1/miR-449a/DLL1 signaling in diabetic rats
Journal: Neurogastroenterology And Motility
DOI: 10.1111/nmo.14843
IF: 3.5
Application: WB
Reactivity: Rat
Publish date: 2024 Jun
-
Suppression of STK39 weakens the MASLD/MASH process by protecting the intestinal barrier
Journal: Bioscience Trends
DOI:
IF: 5.7
Application: WB
Reactivity: Mouse
Publish date: 2024 Jul
-
Knockout of C1q/tumor necrosis factor-related protein-9 aggravates cardiac fibrosis in diabetic mice by regulating YAP-mediated autophagy
Journal: Frontiers In Pharmacology
DOI: 10.3389/fphar.2024.1407883
IF: 4.4
Application: WB,IF-cell
Reactivity: Mouse
Publish date: 2024 Jul
-
Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma
Journal: Respiratory Research
DOI:
IF: 4.7
Application: WB
Reactivity: Human,Mouse
Publish date: 2024 Jul
-
A Dual Role of Mesenchymal Stem Cell Derived Small Extracellular Vesicles on TRPC6 Protein and Mitochondria to Promote Diabetic Wound Healing
Journal: ACS Applied Nano Materials
DOI: 10.1021/acsnano.3c09814
IF: 15.8
Application: WB
Reactivity: Rat
Publish date: 2024 Jan
-
circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis
Journal: Cell Biology And Toxicology
DOI:
IF: 6.1
Application: WB
Reactivity: Human
Publish date: 2024 Jan
-
Shen-Shuai-II-Recipe inhibits tubular inflammation by PPARα-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys
Journal: Phytomedicine
DOI:
IF: 7.9
Application: WB
Reactivity: Rat
Publish date: 2024 Feb
-
miR-193b-5p promotes GCRV replication by inhibiting autophagy via targeting deptor in grass carp (Ctenopharyngodon idellus)
Journal: Fish & Shellfish Immunology
DOI: 10.1016/j.fsi.2024.109453
IF: 4.1
Application: WB
Reactivity: Ctenopharyngodon
Publish date: 2024 Feb
-
Niclosamide - encapsulated lipid nanoparticles for the reversal of pulmonary fibrosis
Journal: Materials Today Bio
DOI:
IF: 8.7
Application: WB
Reactivity: Mouse
Publish date: 2024 Feb
-
Decoding the Cell Atlas and Inflammatory Features of Human Intracranial Aneurysm Wall by Single‐Cell RNA Sequencing
Journal: Journal Of The American Heart Association
DOI: 10.1161/JAHA.123.032456
IF: 5
Application: IF-tissue
Reactivity: Human
Publish date: 2024 Feb
-
A Novel Nanoscale Phase-Change Contrast Agent Evaluates the Hepatic Fibrosis Through Targeting Hepatic Stellate Cell Platelet-Derived Factor Beta Receptor by Ultrasound in Vitro
Journal: Ultrasound In Medicine & Biology
DOI:
IF: 2.4
Application: IF-cell
Reactivity: Rat
Publish date: 2024 Dec
-
Salvianolic acid C promotes renal gluconeogenesis in fibrotic kidneys through PGC1α
Journal: Biochemical And Biophysical Research Communications
DOI: 10.1016/j.bbrc.2024.151174
IF: 2.5
Application: WB
Reactivity: Mouse
Publish date: 2024 Dec
-
Tanshinone I improves renal fibrosis by promoting gluconeogenesis through upregulation of peroxisome proliferator-activated receptor-γ coactivator 1α
Journal: Chronic Kidney Disease And Progression
DOI:
IF: 3
Application: WB
Reactivity: Human
Publish date: 2024 Dec
-
Lactobacillus-Polydopamine System for Targeted Drug Delivery in Overactive Bladder: Evidence from Bladder Cell Spheroids, Rat Models, and Urinary Microbiome Profiling
Journal: International Journal Of Nanomedicine
DOI:
IF: 6.6
Application: IF-cell
Reactivity: Human
Publish date: 2024 Aug
-
Targeted ultrasound-mediated molecular diagnosis and tumor microenvironment remodeling of pancreatic cancer with aPD-L1-modified docetaxel-loaded phase-transition nanoparticles
Journal: Preprint And Has Not Been Certified By Peer Review
DOI:
IF:
Application: IF-cell
Reactivity: Mouse
Publish date: 2024 Aug
-
The combination of paeoniflorin and metformin synergistically inhibits the progression of liver fibrosis in mice
Journal: European Journal Of Pharmacology
DOI:
IF: 4.2
Application: WB,IHC-P
Reactivity: Mouse
Publish date: 2024 Aug
-
DIREN mitigates DSS-induced colitis in mice and attenuates collagen deposition via inhibiting the Wnt/β-catenin and focal adhesion pathways
Journal: Biomedicine & Pharmacotherapy
DOI:
IF: 7.5
Application: IF-cell
Reactivity: Mouse
Publish date: 2024 Apr
-
CARD9 deficiency aggravated nonalcoholic steatohepatitis in mice through increasing inflammatory response
Journal: Biochimica Et Biophysica Acta (Bba) - Molecular Basis Of Disease
DOI: 10.1016/j.bbadis.2023.166893
IF: 6.2
Application: WB
Reactivity: Mouse
Publish date: 2023 Sept
-
SDMA attenuates renal tubulointerstitial fibrosis through inhibition of STAT4
Journal: Journal Of Translational Medicine
DOI:
IF: 8.440
Application: WB
Reactivity: Mouse
Publish date: 2023 May
-
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
Journal: Journal Of Applied Oral Science
DOI:
IF: 3.144
Application: IHC-P
Reactivity: Rat
Publish date: 2023 May
-
The impact and mechanism of TET3 overexpression on the progression of hepatic fibrosis
Journal: Epigenomics
DOI:
IF: 3.8
Application: WB
Reactivity: Mouse
Publish date: 2023 May
-
Hypoxia Drives Material-Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid-Loaded Macrophage Axis
Journal: Advanced Science
DOI:
IF:
Application: IF-tissue
Reactivity: Mouse
Publish date: 2023 May
-
Shen Shuai II Recipe inhibits hypoxia-induced glycolysis by preserving mitochondrial dynamics to attenuate kidney fibrosis
Journal: Journal Of Ethnopharmacology
DOI:
IF: 5.4
Application: WB
Reactivity: Rat
Publish date: 2023 May
-
TRIM21 deficiency protects against atrial inflammation and remodeling post myocardial infarction by attenuating oxidative stress
Journal: Redox Biology
DOI:
IF: 11.4
Application: WB
Reactivity: Mouse
Publish date: 2023 Jun
-
Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38
Journal: Phytomedicine
DOI:
IF:
Application: WB
Reactivity: Mouse
Publish date: 2023 Jan
-
Icariside II prevents kidney fibrosis development in chronic kidney disease by promoting fatty acid oxidation
Journal: Phytotherapy Research
DOI: 10.1002/ptr.8085
IF: 7.2
Application: WB
Reactivity: Rat
Publish date: 2023 Dec
-
Long non-coding RNA MALAT1 sponges miR-30c to promote the calcification of human vascular smooth muscle cells by regulating Runx2
Journal: Renal Failure
DOI:
IF: 3.222
Application: WB
Reactivity: Human
Publish date: 2023 Dec
-
A cancer-associated fibroblast subtypes-based signature enables the evaluation of immunotherapy response and prognosis in bladder cancer
Journal: iScience
DOI:
IF: 5.8
Application: IF-cell
Reactivity: Human
Publish date: 2023 Aug
-
ZNF32 prevents the activation of cancer‐associated fibroblasts through negative regulation of TGFB1 transcription in breast cancer
Journal: FASEB Journal
DOI:
IF: 4.8
Application: WB
Reactivity: Mouse
Publish date: 2023 Apr
-
Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis
Journal: Cells
DOI:
IF: 7.666
Application: WB
Reactivity: Rat
Publish date: 2022 Nov
-
The TL1A-DR3 Axis in Asthma: Membrane-Bound and Secreted TL1A Co-Determined the Development of Airway Remodeling
Journal: Allergy Asthma & Immunology Research
DOI:
IF: 5.764
Application: WB
Reactivity: Human
Publish date: 2022 Mar
-
Loss of TRIM67 attenuates the progress of obesity-induced non-alcoholic fatty liver disease
Journal: International Journal Of Molecular Sciences
DOI:
IF: 5.6
Application: WB,IHC-P
Reactivity: Mouse
Publish date: 2022 Jul
-
Shen Shuai Ⅱ Recipe attenuates renal fibrosis in chronic kidney disease by improving hypoxia-induced the imbalance of mitochondrial dynamics via PGC-1α activation
Journal: Phytomedicine
DOI:
IF: 7.9
Application: WB
Reactivity: Human
Publish date: 2022 Jan
-
Natural Flavonoid Pectolinarigenin Alleviated Hyperuricemic Nephropathy via Suppressing TGFβ/SMAD3 and JAK2/STAT3 Signaling Pathways
Journal: Frontiers In Pharmacology
DOI:
IF: 5.810
Application: WB,IHC-P
Reactivity: Mouse
Publish date: 2022 Jan
-
Discovery of indol-6-yl-pyrrolo[2,3-c]pyridin-7-one derivatives as bromodomain-containing protein 4 (BRD4) inhibitors for the treatment of kidney fibrosis
Journal: European Journal Of Medicinal Chemistry
DOI: 10.1016/j.ejmech.2022.114153
IF: 7.088
Application: IHC-P
Reactivity: Mouse
Publish date: 2022 Feb
-
Salvianolic acid B attenuates tubulointerstitial fibrosis by inhibiting EZH2 to regulate the PTEN/Akt pathway
Journal: Pharmaceutical Biology
DOI:
IF: 3.889
Application: WB
Reactivity: Mouse
Publish date: 2022 Dec
-
Gambogenic acid alleviates kidney fibrosis via epigenetic inhibition of EZH2 to regulate Smad7-dependent mechanism
Journal: Phytomedicine
DOI: 10.1016/j.phymed.2022.154390
IF: 6.656
Application: IHC-P
Reactivity: Mouse
Publish date: 2022 Aug
-
Oxidative stress-mediated mitochondrial fission promotes hepatic stellate cell activation via stimulating oxidative phosphorylation
Journal: Cell Death & Disease
DOI:
IF: 9.685
Application: IHC-P
Reactivity: Mouse
Publish date: 2022 Aug
-
Follistatin-related protein 1 in asthma: miR-200b-3p interactions affect airway remodeling and inflammation phenotype
Journal: International Immunopharmacology
DOI:
IF: 5.6
Application: WB
Reactivity: Human
Publish date: 2022 Aug
-
Silencing of YAP attenuates pericyte-myofibroblast transition and subretinal fibrosis in experimental model of choroidal neovascularization
Journal: Cell Biology International
DOI: 10.1002/cbin.11809
IF: 4.473
Application: WB
Reactivity: Human
Publish date: 2022 Apr
-
Tanshinone I attenuates fibrosis in fibrotic kidneys through down-regulation of inhibin beta-A
Journal: BMC Complementary Medicine and Therapies
DOI:
IF: 2.838
Application: WB
Reactivity: Mouse
Publish date: 2022 Apr
-
Inhibiting the Cytosolic Phospholipase A2–Arachidonic Acid Pathway With Arachidonyl Trifluoromethyl Ketone Attenuates Radiation-Induced Lung Fibrosis
Journal: International Journal Of Radiation Oncology Biology Physics
DOI: 10.1016/j.ijrobp.2022.03.008
IF: 8.013
Application: IHC-P
Reactivity: Mouse
Publish date: 2022 Apr
-
Pharmacologic inhibiting STAT3 delays the progression of kidney fibrosis in hyperuricemia-induced chronic kidney disease
Journal: Life Sciences
DOI: 10.1016/j.lfs.2021.119946
IF: 5.037
Application: WB
Reactivity: Mouse
Publish date: 2021 Sept
-
Fisetin Improves Hyperuricemia-Induced Chronic Kidney Disease via Regulating Gut Microbiota-Mediated Tryptophan Metabolism and Aryl Hydrocarbon Receptor Activation
Journal: Journal Of Agricultural And Food Chemistry
DOI: 10.1021/acs.jafc.1c03449
IF: 5.279
Application: WB
Reactivity: Mouse
Publish date: 2021 Sept
-
Icariin attenuates renal fibrosis in chronic kidney disease by inhibiting interleukin‐1β/transforming growth factor‐β‐mediated activation of renal fibroblasts
Journal: Phytotherapy Research
DOI:
IF: 7.2
Application: WB
Reactivity: Rat
Publish date: 2021 Nov
-
TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis
Journal: Toxicology And Applied Pharmacology
DOI:
IF: 4.211
Application: WB,IHC-P
Reactivity: Mouse
Publish date: 2021 May
-
Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys. Frontiers in pharmacology, 12, 626510.
Journal: Frontiers In Pharmacology
DOI:
IF: 5.814
Application: WB
Reactivity: Rat
Publish date: 2021 Jul
-
Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-β/SMAD3 signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology, 87, 153552.
Journal: Phytomedicine
DOI:
IF: 4.268
Application: WB,IHC-P
Reactivity: Mouse
Publish date: 2021 Jul
-
METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial–mesenchymal transition of renal tubular cells in diabetic kidney disease
Journal: Cell Death & Disease
DOI:
IF: 8.462
Application: WB
Reactivity: Mouse
Publish date: 2021 Jan
-
Natural flavonoid pectolinarigenin alleviated kidney fibrosis via inhibiting the activation of TGFβ/SMAD3 and JAK2/STAT3 signaling. International immunopharmacology, 91, 107279.
Journal: International Immunopharmacology
DOI:
IF: 3.94
Application: WB
Reactivity: Mouse
Publish date: 2021 Feb
-
Inhibition of Fatty Acid–Binding Protein 4 Attenuated Kidney Fibrosis by Mediating Macrophage-to-Myofibroblast Transition
Journal: Frontiers In Immunology
DOI:
IF: 5.085
Application: WB
Reactivity: Human,Mouse
Publish date: 2020 Sep
-
Renal asymmetric dimethylarginine inhibits fibrosis
Journal: Renal Adma And Fibrosis
DOI:
IF: 2.231
Application: WB
Reactivity: Mouse
Publish date: 2020 Oct
-
Pterostilbene, a bioactive component of blueberries, alleviates renal interstitial fibrosis by inhibiting macrophage-myofibroblast transition
Journal: American Journal Of Chinese Medicine
DOI:
IF: 5.7
Application: WB
Reactivity: Mouse
Publish date: 2020 Nov
-
The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model
Journal: Public Library Of Science One
DOI:
IF: 2.74
Application: IHC-P
Reactivity: Mouse
Publish date: 2020 Dec
-
Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys.
Journal: FASEB Journal
DOI:
IF: 5.391
Application: WB
Reactivity: Human
Publish date: 2019 Jun
-
Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 109, 1802–1808.
Journal: Biomedicine & Pharmacotherapy
DOI:
IF: 3.457
Application: WB
Reactivity: Mouse
Publish date: 2019 Jan
Products with the same target and pathway
alpha smooth muscle Actin Recombinant Rabbit Monoclonal Antibody [SY02-64] - BSA and Azide free
Application: WB,IF-Cell,IF-Tissue,IHC-P,FC
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
alpha smooth muscle Actin Recombinant Antibody [SY02-64] - Mouse IgG1 (Chimeric) - BSA and Azide free
Application: WB,IHC-P,IF-Cell,FC
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
alpha smooth muscle Actin Recombinant Antibody - Mouse IgG1 (Chimeric)
Application: mIHC
Reactivity: Human
Conjugate: unconjugated
alpha smooth muscle Actin Recombinant Rabbit Monoclonal Antibody [SY25-03]
Application: WB,IHC-P,FC,IP
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
alpha smooth muscle Actin Recombinant Antibody - Rat IgG1 (Chimeric)
Application: mIHC
Reactivity: Human
Conjugate: unconjugated
alpha smooth muscle Actin Recombinant Antibody [SY02-64] - Mouse IgG1 (Chimeric)
Application: WB,IHC-P,IF-Cell,FC,mIHC
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
