Claudin 5 Recombinant Rabbit Monoclonal Antibody [JM11-22] (ET1703-58)

UNIPROT #

O00501

PROTEIN NAME

Claudin 5

SYNONYMS

Androgen withdrawal and apoptosis induced protein RVP1 like antibody;AWAL antibody;BEC 1 antibody;BEC1 antibody;Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) antibody;Claudin-5 antibody;Claudin5 antibody;CLD5_HUMAN antibody;CLDN 5 antibody;Cldn5 antibody;CPETR L1 antibody;CPETRL 1 antibody;CPETRL1 antibody;TMDVCF antibody;TMVCF antibody;Transmembrane protein deleted in VCFS antibody;Transmembrane protein deleted in velocardiofacial syndrome antibody

SEQUENCE SIMILARITIES

Belongs to the claudin family.

SUBCELLULAR LOCATION

Cell junction. Cell membrane.

FUNCTION

The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-5 is expressed in the endothelial junctions of the rat liver and in junctions of acinar cells of the pancreas. Human Claudin-5 is abundantly expressed in adult lung, heart and skeletal muscle and is deleted in patients with velocardiofacial syndrone, which is characterized by cleft palate, facial dysmorphology and conotruncal heart defects.