Glucose Transporter GLUT3 Recombinant Rabbit Monoclonal Antibody [JA50-31] (ET1704-59)

UNIPROT #

P11169

PROTEIN NAME

Glucose Transporter GLUT3

SYNONYMS

brain antibody;FLJ90380 antibody;Glucose transporter type 3 antibody;Glucose transporter type 3 brain antibody;GLUT 3 antibody;GLUT-3 antibody;GLUT3 antibody;GTR3_HUMAN antibody;Slc2a3 antibody;Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3 antibody;Solute carrier family 2, facilitated glucose transporter member 3 antibody

SEQUENCE SIMILARITIES

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

TISSUE SPECIFICITY

Highly expressed in brain. Expressed in many tissues.

SUBCELLULAR LOCATION

Cell membrane. Perikaryon. Cell projection.

FUNCTION

Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. Glut1, Glut3 and Glut4 are high-affinity transporters, whereas Glut2 is a low-affinity transporter. In adipose and muscle tissue, Insulin stimulates a rapid and dramatic increase in glucose uptake, largely due to the redistribution of the Insulin-inducible glucose transporter, Glut4. In response to Insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane and shows a much less dramatic translocation in response to Insulin. Glut2 expression is seen in pancreatic b cells, hepatocytes and basolateral membranes of intestinal and epithelial cells, while the highest expression of Glut3 has been found in neuronal tissue.