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Heme Oxygenase 1(HO-1) Recombinant Rabbit Monoclonal Antibody [SP08-07] (ET1604-45)

Price: Regular price $385.00

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Catalog# ET1604-45

Rabbit Monoclonal to Heme Oxygenase 1(HO-1)

Tested for

  • WB

  • IHC-P

  • IP

  • FC

  • IF-Tissue

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Heme Oxygenase 1(HO-1) Recombinant Rabbit Monoclonal Antibody [SP08-07] (ET1604-45)

Immunogen

Synthetic peptide within human ho-1 aa 227-276 / 288.

Host

Rabbit

Positive Control

Human spleen tissue, human liver tissue, Jurkat.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SP08-07

RRID

AB_3069700

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IHC-P

  • 1:50-1:1,000

  • FC

  • 1:500-1:1,000

  • IP

  • Use at an assay dependent concentration.

  • IF-Tissue

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 33 kDa

Isotype

IgG

TARGET

UNIPROT #

P09601

PROTEIN NAME

Heme Oxygenase 1(HO-1)

SYNONYMS

32 kD antibody;bK286B10 antibody;D8Wsu38e antibody;heat shock protein 32 kD antibody;heat shock protein 32kD antibody;Heat shock protein antibody;Heme oxygenase (decycling) 1 antibody;Heme oxygenase 1 antibody;Hemox antibody;HMOX 1 antibody;Hmox antibody;Hmox1 antibody;HMOX1_HUMAN antibody;HO 1 antibody;HO antibody;HO-1 antibody;HO1 antibody;Hsp32 antibody

SEQUENCE SIMILARITIES

Belongs to the heme oxygenase family.

TISSUE SPECIFICITY

Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

Heme oxygenases are microsomal enzymes that cleave heme to produce the antioxidant biliverdin, inorganic iron and carbon monoxide (CO). The activity of Heme Oxygenase 1 (HO-1), also designated HSP 32, is highly inducible in response to numerous stimuli, including heme, heavy metals, hormones and oxidative stress. Heme Oxygenase 2, in contrast, appears to be constituitively expressed in mammalian tissues. Heme Oxygenase 2 is involved in the production of carbon monoxide (CO) in brain, where CO is thought to act as a neurotransmitter. The CO signaling system closely parallels the signaling pathway involving nitric oxide, and regulation of the two systems is closely linked. Heme Oxygenase 3 is found in the spleen, liver, thymus, prostate, heart, kidney, brain and testis. A poor heme catalyst, Heme Oxygenase 3 has two heme regulatory motifs that may be involved in heme binding.

CITATIONS

  • Shikonin and cisplatin synergistically overcome cisplatin resistance of ovarian cancer by inducing ferroptosis via upregulation of HMOX1 to promote Fe2+ accumulation

  • Iron-overload-induced ferroptosis in mouse cerebral toxoplasmosis promotes brain injury and could be inhibited by Deferiprone

  • Shao Chunyan,et al

    Selenium nanoparticles alleviates cadmium induced hepatotoxicity by inhibiting ferroptosis and oxidative stress in vivo and in vitro

  • Yuan, H., Xu, Y., Luo, Y., Zhang, J. R., Zhu, X. X., & Xiao, J. H.

    Ganoderic acid D prevents oxidative stress-induced senescence by targeting 14-3-3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells

  • Zhang Yiyuan,et al

    SBFI26 induces triple- negative breast cancer cells ferroptosis via lipid peroxidation

  • Yizhen Wang

    Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling

  • Protective effect of rutin on ferroptosis‐induced oxidative stress in aging laying hens through Nrf2/HO‐1 signaling

  • Cen Qingyan,et al

    CLPs-miR-103a-2-5p inhibits proliferation and promotes cell apoptosis in AML cells by targeting LILRB3 and Nrf2/HO-1 axis, regulating CD8 + T cell response

  • Identification, in silico selection, and mechanism study of novel antioxidant peptides derived from the rice bran protein hydrolysates

  • Silencing of HMOX1 enhances apoptosis caused by arsenic trioxide in HCC

  • Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity

  • Jiang SJ, Xiao X, Li J, Mu Y

    Lycium barbarum polysaccharide-glycoprotein ameliorates ionizing radiation-induced epithelial injury by regulating oxidative stress and ferroptosis via the Nrf2 pathway

  • Liu Y, Lin M, Mu X, et al

    Protective effect of solanesol in glucose-induced hepatocyte injury: Mechanistic insights on oxidative stress and mitochondrial preservation

  • Han, H., Xu, B., Amin, A., Li, H., Yu, X., Gong, M., & Zhang, L.

    Quercetin‑3‑O‑α‑L‑rhamnopyranoside derived from the leaves of Lindera aggregata (Sims) Kosterm. evokes the autophagy‑induced nuclear factor erythroid 2‑related factor 2 antioxidant pathway in human umbilical vein endothelial cells. International journal of molecular medicine, 43(1), 461–474.

  • Identification and in silico analysis of novel antioxidant peptides in broken rice protein hydrolysate and its cytoprotective effect against H2O2-induced 2BS cell model

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