HLA-DR Recombinant Rabbit Monoclonal Antibody [SC06-78] (ET1610-66)

UNIPROT #

P01903

PROTEIN NAME

HLA-DR

SYNONYMS

DR alpha chain antibody;DR alpha chain precursor antibody;DRA_HUMAN antibody;DRB1 antibody;DRB4 antibody;Histocompatibility antigen HLA DR alpha antibody;HLA class II histocompatibility antigen antibody;HLA class II histocompatibility antigen DR alpha chain antibody;HLA DR1B antibody;HLA DR3B antibody;HLA DRA antibody;HLA DRA1 antibody;HLA DRB1 antibody;HLA DRB3 antibody;HLA DRB4 antibody;HLA DRB5 antibody;HLA-DRA antibody;HLADR4B antibody;HLADRA1 antibody;HLADRB antibody;Major histocompatibility complex class II DR alpha antibody;Major histocompatibility complex class II DR beta 1 antibody;Major histocompatibility complex class II DR beta 3 antibody;Major histocompatibility complex class II DR beta 4 antibody;Major histocompatibility complex class II DR beta 5 antibody;MGC117330 antibody;MHC cell surface glycoprotein antibody;MHC class II antigen DRA antibody;MHC II antibody;MLRW antibody

SEQUENCE SIMILARITIES

Belongs to the MHC class II family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by MARCH1 or MARCH8 at Lys-244 leading to down-regulation of MHC class II. When associated with ubiquitination of the beta subunit of HLA-DR: HLA-DRB4 'Lys-254', the down-regulation of MHC class II may be highly effective.

SUBCELLULAR LOCATION

Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus, Endosome membrane, Lysosome membrane.

FUNCTION

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II α/β dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (β-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.