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JAK2 Recombinant Rabbit Monoclonal Antibody [SY0245] (ET1607-35)

Price: Regular price $385.00

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Catalog# ET1607-35

Rabbit Monoclonal to JAK2

Tested for

  • WB

  • IF-Cell

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

JAK2 Recombinant Rabbit Monoclonal Antibody [SY0245] (ET1607-35)

Immunogen

Synthetic peptide within c-terminal human jak2.

Host

Rabbit

Positive Control

TF-1 cell lysate, K-562 cell lysate, THP-1 cell lysate, RAW264.7 cell lysate, C6 cell lysate, Jurkat cell lysate, MEF cell lysate, A549, MCF-7, NIH/3T3.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SY0245

RRID

AB_3069760

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IF-Cell

  • 1:100-1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 131 kDa

Isotype

IgG

TARGET

UNIPROT #

O60674

PROTEIN NAME

JAK2

SYNONYMS

JAK 2 antibody;JAK-2 antibody;JAK2 antibody;JAK2_HUMAN antibody;Janus Activating Kinase 2 antibody;Janus kinase 2 (a protein tyrosine kinase) antibody;Janus kinase 2 antibody;JTK 10 antibody;JTK10 antibody;kinase Jak2 antibody;OTTHUMP00000043260 antibody;THCYT3 antibody;Tyrosine protein kinase JAK2 antibody;Tyrosine-protein kinase JAK2 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

TISSUE SPECIFICITY

Ubiquitously expressed throughout most tissues.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813 (By similarity). Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity (By similarity). Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity (By similarity). Also phosphorylated by TEC (By similarity). Phosphorylated on tyrosine residues in response to interferon gamma signaling. Phosphorylated on tyrosine residues in response to a signaling cascade that is activated by increased cellular retinol.

SUBCELLULAR LOCATION

Endomembrane system, Cytoplasm, Nucleus.

FUNCTION

JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

CITATIONS

  • Wang Yingying,et al

    Linderae Radix extract attenuates ulcerative colitis by inhibiting the JAK/STAT signaling pathway

  • Gu, X., Miao, Z., Wang, Y., Yang, Y., Yang, T., & Xu, Y.

    New Baitouweng decoction combined with fecal microbiota transplantation alleviates DSS-induced colitis in rats by regulating gut microbiota metabolic homeostasis and the STAT3/NF-κB signaling pathway

  • Novel synthetic 4-chlorobenzoyl berbamine inhibits c-Myc expression and induces apoptosis of diffuse large B cell lymphoma cells.

  • Liu, Y., Hao, Y., Zhao, H., Zhang, Y., Cheng, D., Zhao, L., Peng, Y., Lu, Y., & Li, Y.

    PlexinA1 activation induced by β2-AR promotes epithelial-mesenchymal transition through JAK-STAT3 signaling in human gastric cancer cells

  • Osteoclast-Derived Exosomal miR-5134-5p Interferes with Alveolar Bone Homeostasis by Targeting the JAK2/STAT3 Axis

  • Fu, Y., Peng, Y., Zhao, S., Mou, J., Zeng, L., Jiang, X., Yang, C., Huang, C., Li, Y., Lu, Y., Wu, M., Yang, Y., Kong, T., Lai, Q., Wu, Y., Yao, Y., Wang, Y., Gou, L., & Yang, J.

    Combination Foretinib and Anti-PD-1 Antibody Immunotherapy for Colorectal Carcinoma. Frontiers in cell and developmental biology, 9, 689727.

  • Du Xingde,et al

    Environmentally related microcystin-LR-induced ovarian dysfunction via the CCL2-CCR10 axis in mice ameliorated by dietary mulberry

  • Acute myeloid leukemia (AML)‐derived mesenchymal stem cells induce chemoresistance and epithelial–mesenchymal transition‐like program in AML through IL‐6/JAK2/STAT3 signaling

  • "Drying effect" of fructus aurantii components and the mechanism of action based on network pharmacology and in vitro pharmacodynamic validation

  • Preparation of Ultra-Small Copper Nanoparticles-Loaded Self-Healing Hydrogels with Antibacterial, Inflammation-Suppressing and Angiogenesis-Enhancing Properties for Promoting Diabetic Wound Healing

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