KDM5B Rabbit Polyclonal Antibody (ER1802-21)

UNIPROT #

Q9UGL1

PROTEIN NAME

KDM5B

SYNONYMS

Cancer/testis antigen 31 antibody;CT31 antibody;Histone demethylase JARID1B antibody;JARID1B antibody;Jumonji AT rich interactive domain 1B antibody;Jumonji/ARID domain-containing protein 1B antibody;Kdm5b antibody;KDM5B_HUMAN antibody;Lysine (K) specific demethylase 5B antibody;Lysine demethylase 5B antibody;Lysine specific demethylase 5B antibody;Lysine-specific demethylase 5B antibody;PLU-1 antibody;PLU1 antibody;PPP1R98 antibody;Protein phosphatase 1 regulatory subunit 98 antibody;PUT1 antibody;putative DNA/chromatin binding motif antibody;RBBP2H1A antibody;RBP2 like antibody;RBP2-H1 antibody;Retinoblastoma-binding protein 2 homolog 1 antibody;Retinoblastoma-binding protein 2 homolog 1A antibody

SEQUENCE SIMILARITIES

Belongs to the JARID1 histone demethylase family.

TISSUE SPECIFICITY

Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

PLU-1 is a large (1,544 amino acid) nuclear protein that interacts with brain factor-1 (BF-1) and paired box 9 (PAX9), both of which are developmental transcription factors. PLU-1 belongs to the testis-cancer antigen group of proteins and is a member of the ARID family of DNA binding proteins. It is a multi-domain protein with strong transcriptional repression properties. PLU-1 shows restricted expression in adult tissues, with high expression in testis and transient expression in the pregnant mammary gland. Both the PLU-1 gene and the PLU-1 protein product are specifically upregulated in breast cancer. PLU-1 may be important in meiotic transcription because of its apparent association with chromatin.