Lin28B Mouse Monoclonal Antibody [A2-4-5] (M1312-1)

UNIPROT #

Q6ZN17

PROTEIN NAME

Lin28B

SYNONYMS

CSDD 2 antibody;CSDD2 antibody;FLJ16517 antibody;Lin 28 homolog B (C. elegans) antibody;Lin 28.2 antibody;Lin-28B antibody;LIN28B antibody;LN28B_HUMAN antibody;Protein lin-28 homolog B antibody

SEQUENCE SIMILARITIES

Belongs to the lin-28 family.

TISSUE SPECIFICITY

Expressed at high levels in the placenta and, at mucher lower, in testis and fetal liver. Isoform 1 is only detected in placenta and in moderately and poorly differentiated hepatocellular carcinoma cells (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level). Tends to be up-regulated in triple-negative (ER-,PR-,HER2-) breast tumors, as well as in liver, ovarian, and thyroid carcinomas.

SUBCELLULAR LOCATION

Cytoplasm, nucleus

FUNCTION

LIN28 is thought to regulate the self-renewal of stem cells. In nematodes, the LIN28 homolog lin-28 is a heterochronic gene that determines the onset of early larval stages of developmental events in Caenorhabditis elegans, by regulating the self-renewal of nematode stem cells in the skin (called seam cells) and vulva (called VPCs) during development. In mice, LIN28 is highly expressed in mouse embryonic stem cells and during early embryogenesis.It acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Lin28B is high expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC).