macroH2A.1 Rabbit Polyclonal Antibody (ER1803-04)

UNIPROT #

O75367

PROTEIN NAME

macroH2A.1

SYNONYMS

Core histone macro h2a.1 antibody;Core histone macro-H2A.1 antibody;H2A histone family member Y antibody;H2A.y antibody;H2A/y antibody;H2AF12M antibody;H2AFJ antibody;H2afy antibody;H2AY_HUMAN antibody;Histone H2A.Y antibody;Histone macroH2A1 antibody;Histone macroH2A1.1 antibody;Histone macroH2A1.2 antibody;Macroh2a1 antibody;MACROH2A1.1 antibody;MacroH2A1.2 antibody;Medulloblastoma antigen MU MB 50.205 antibody;Medulloblastoma antigen MU-MB-50.205 antibody;mH2a antibody;mH2A1 antibody

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin.