MCM3 Recombinant Rabbit Monoclonal Antibody [JB99-35] (ET7107-66)

UNIPROT #

P25205

PROTEIN NAME

MCM3

SYNONYMS

Cervical cancer proto oncogene 5 antibody;DNA polymerase alpha holoenzyme associated P1 antibody;DNA polymerase alpha holoenzyme associated protein P1 antibody;DNA polymerase alpha holoenzyme-associated protein P1 antibody;DNA replication factor MCM3 antibody;DNA replication licensing factor mcm3 antibody;HCC 5 antibody;HCC5 antibody;hRlf beta subunit antibody;Human cervical cancer proto oncogene 5 antibody;MCM 3 antibody;mcm3 antibody;MCM3 minichromosome maintenance deficient 3 antibody;MCM3_HUMAN antibody;MGC1157 antibody;Minichromosome maintenance complex component 3 antibody;Minichromosome maintenance deficient 3 antibody;Minichromosome maintenance protein 3 antibody;P1 h antibody;P1 MCM3 antibody;P1 Protein antibody;P1-MCM3 antibody;P1.h antibody;p102 antibody;P102 protein antibody;Replication licensing factor beta subunit antibody;RLF beta subunit antibody;RLF subunit beta antibody;RLFB antibody

SEQUENCE SIMILARITIES

Belongs to the MCM family.

POST-TRANSLATIONAL MODIFICATION

Acetylated by MCM3AP.; O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

SUBCELLULAR LOCATION

Chromosome, Nucleus.

FUNCTION

The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation during apoptosis of the MCM complex, which is composed of, at least, MCM2–6. A complex composed of MCM4, MCM6 and MCM7 has been shown to be involved in DNA helicase activity, and MCM5 is involved in IFN-γ-induced Stat1α transcription activation.