MUC2 Recombinant Rabbit Monoclonal Antibody [JA10-92] (ET1704-06)

UNIPROT #

Q02817

PROTEIN NAME

MUC2

SYNONYMS

Intestinal mucin 2 antibody;Intestinal mucin-2 antibody;MLP antibody;MUC 2 antibody;MUC-2 antibody;Muc2 antibody;MUC2_HUMAN antibody;Mucin 2 antibody;Mucin 2 intestinal antibody;Mucin 2 intestinal/tracheal antibody;Mucin 2 oligomeric mucus/gel forming antibody;Mucin 2 precursor antibody;Mucin 2 tracheal antibody;Mucin like protein antibody;Mucin-2 antibody;Mucin2 antibody;SMUC antibody

TISSUE SPECIFICITY

Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated.; May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.; At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3). The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major com-ponent of various mucus gels and is broadly expressed in normal and tumor cells.