NeuroD2 Recombinant Rabbit Monoclonal Antibody [JE50-57] (ET7110-17)

UNIPROT #

Q15784

PROTEIN NAME

NeuroD2

SYNONYMS

bHLHa1 antibody;class A basic helix loop helix protein 1 antibody;Class A basic helix-loop-helix protein 1 antibody;NDF2_HUMAN antibody;NDR2 antibody;NDRF antibody;neuroD related factor antibody;NeuroD-related factor antibody;NeuroD2 antibody;neurogenic basic helix loop helix protein antibody;neurogenic differentiation 2 antibody;Neurogenic differentiation factor 2 antibody;neuronal differentiation 2 antibody

TISSUE SPECIFICITY

Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum (at protein level). Expressed in layers V and VI of the neocortex at postnatal day 1. Expressed in all layers of the neocortex at postnatal day 4. Strongly expressed in layer IV of the neocortex, particularly in the barrel cortex at postnatal day 7. Expressed in the CA1, CA2 and CA3 and dentate gyrus of the hippocampus and many nuclei such as the habenular thalamic nuclei, paraventricular hypothalamic nuclei, amygdala nuclei, and pyramidal nucleus. Expressed in granule cells, molecular layer neurons, and deep cerebella nuclei of the cerebellum. Expressed in brainstem neurons in the external cuneate nucleus and central gray.

DEVELOPMENTAL STAGE

Expressed in dorsal and ventral parts of the lateral, basolateral and basomedial amygdala at 17 and 18 dpc (at protein level). Initially expressed in embryo at 11 dpc, with persistent expression in the nervous system until birth.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by the APC/C complex; leading to its degradation in neurons. The CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).