PABPN1 Recombinant Rabbit Monoclonal Antibody [JM11-28] (ET1703-66)

UNIPROT #

Q86U42

PROTEIN NAME

PABPN1

SYNONYMS

Nuclear poly(A)-binding protein 1 antibody;OPMD antibody;PAB2 antibody;PABII antibody;PABP 2 antibody;pABP-2 antibody;PABP2 antibody;PABP2_HUMAN antibody;PABPII antibody;Pabpn1 antibody;poly(A) binding protein nuclear 1 antibody;Poly(A)-binding protein 2 antibody;Poly(A)-binding protein II antibody;PolyA binding protein II antibody;Polyadenylate-binding nuclear protein 1 antibody;Polyadenylate-binding protein 2 antibody

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Arginine dimethylation is asymmetric and involves PRMT1 and PRMT3. It does not influence the RNA binding properties (By similarity).

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation.