Phospho-PI3K p85+PI3K p55 (p85(pY467)+p55(pY199)) Recombinant Rabbit Monoclonal Antibody [PSH01-38] (HA721672)

UNIPROT #

P27986

PROTEIN NAME

Phospho-PI3K p85+PI3K p55 (p85(pY467)+p55(pY199))

SYNONYMS

GRB1 antibody;p85 alpha antibody;p85 antibody;P85A_HUMAN antibody;Phosphatidylinositol 3 kinase associated p 85 alpha antibody;Phosphatidylinositol 3 kinase regulatory 1 antibody;Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 1 (p85 alpha) antibody;Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha antibody;Phosphatidylinositol 3-kinase regulatory subunit alpha antibody;Phosphoinositide 3 kinase, regulatory subunit 1 (alpha) antibody;PI3 kinase p85 antibody;PI3 kinase p85 subunit alpha antibody;PI3-kinase regulatory subunit alpha antibody;PI3-kinase subunit p85-alpha antibody;PI3K antibody;PI3K p85 antibody;PI3K regulatory subunit alpha antibody;Pik3r1 antibody;PtdIns 3 kinase p85 alpha antibody;PtdIns-3-kinase regulatory subunit alpha antibody;PtdIns-3-kinase regulatory subunit p85-alpha antibody

SUBCELLULAR LOCATION

Cell-cell junction, cis-Golgi network, cytoplasm, cytosol, membrane, nucleus.

FUNCTION

Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene. Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms.