PKC mu Recombinant Rabbit Monoclonal Antibody [JM30-17] (ET1705-4)

UNIPROT #

Q15139

PROTEIN NAME

PKC mu

SYNONYMS

KPCD1_HUMAN antibody;nPKC D1 antibody;nPKC mu antibody;nPKC-D1 antibody;nPKC-mu antibody;nPKCD1 antibody;nPKCmu antibody;PKC antibody;PKC MU antibody;PKCM antibody;PKCmu antibody;PKD 1 antibody;PKD antibody;PKD1 antibody;PRKCM antibody;PRKD 1 antibody;Prkd1 antibody;Protein kinase C mu antibody;Protein kinase C mu type antibody;Protein kinase D antibody;Protein kinase D1 antibody;Serine/threonine protein kinase D1 antibody;Serine/threonine-protein kinase D1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Ser-397 and Ser-401 by MAPK13 during regulation of insulin secretion in pancreatic beta cells. Phosphorylated by DAPK1. Phosphorylated at Tyr-95 and by ABL at Tyr-463, which primes the kinase in response to oxidative stress, and promotes a second step activating phosphorylation at Ser-738/Ser-742 by PKRD. Phosphorylated on Ser-910 upon S.enterica infection in macrophages (By similarity).

SUBCELLULAR LOCATION

Cell membrane, trans-Golgi network, Cytoplasm.

FUNCTION

The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response.