Sodium Potassium ATPase Recombinant Rabbit Monoclonal Antibody [ST0533] (ET1609-76)

UNIPROT #

P05023

PROTEIN NAME

Sodium Potassium ATPase

SYNONYMS

ATPase Na+/K+ transporting alpha antibody;adenosinetriphosphatase antibody;AT1A1_HUMAN antibody;ATP1A1 antibody;ATP1A4 antibody;ATP1AL2 antibody;ATP1B antibody;ATP1B1 antibody;ATPase Na+/K+ transporting alpha 1 polypeptide antibody;ATPase Na+/K+ transporting alpha 4 polypeptide antibody;ATPase Na+/K+ transporting beta 1 polypeptide antibody;ATPase, Na+/K+ transporting, alpha polypeptide-like 2 antibody;ATPase, Na+/K+ transporting, beta 1 polypeptide antibody;Beta 1-subunit of Na(+),K(+)-ATPase antibody;Na(+)/K(+) ATPase alpha-1 subunit antibody;Na(+)/K(+) ATPase alpha-4 subunit antibody;Na+, K+ ATPase alpha subunit antibody;Na+/K+ ATPase 1 antibody;Na+/K+ ATPase 4 antibody;Na+/K+ ATPase, alpha-D polypeptide antibody;Na, K-ATPase beta-1 polypeptide antibody;Na, K-ATPase, alpha-A catalytic polypeptide antibody;Na,K-ATPase catalytic subunit alpha-A protein antibody;Na,K-ATPase subunit alpha-C antibody;polypeptide-like 2 antibody;Sodium pump 1 antibody;sodium pump 4 antibody;Sodium pump subunit alpha-1 antibody;sodium pump subunit alpha-4 antibody;sodium pump subunit beta-1 antibody;sodium-potassium ATPase catalytic subunit alpha-1 antibody;sodium-potassium ATPase catalytic subunit alpha-4 antibody;sodium-potassium ATPase subunit beta 1 (non-catalytic) antibody;sodium-potassium ATPase, alpha 4 polypeptide antibody;sodium-potassium-ATPase, alpha 1 polypeptide antibody;Sodium/potassium transporting ATPase alpha 1 chain antibody;Sodium/potassium transporting ATPase subunit beta 1 antibody;sodium/potassium-dependent ATPase beta-1 subunit antibody;sodium/potassium-transporting ATPase alpha-4 chain antibody;sodium/potassium-transporting ATPase beta-1 chain antibody;Sodium/potassium-transporting ATPase subunit alpha-1 antibody;sodium/potassium-transporting ATPase subunit alpha-4 antibody

SEQUENCE SIMILARITIES

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).

SUBCELLULAR LOCATION

Cell membrane, Melanosome.

FUNCTION

The ubiquitously expressed sodium/potassium-ATPase (Na⁺/K⁺-ATPase) exists as an oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na⁺ ions and two K⁺ ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na⁺/K⁺-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Multiple isoforms of three subunits, α, β and γ, comprise the Na⁺/K⁺-ATPase oligomer. The α subunit contains the binding sites for ATP and the cations; the glycosylated β subunit ensures correct folding and membrane insertion of the α subunits. The small γ subunit co-localizes with the α subunit in nephron segments, where it increases the affinity of Na⁺/K⁺-ATPase for ATP. The β subunit, but not the γ subunit, is essential for normal activity of Na⁺/K⁺-ATPase.