STAT6 Rabbit Polyclonal Antibody (ER40121)

UNIPROT #

P42226

PROTEIN NAME

STAT6

SYNONYMS

12S1644 antibody;D12S1644 antibody;IL 4 STAT antibody;IL-4 Stat antibody;IL4 STAT antibody;Interleukin 4 Induced antibody;Interleukin 4 Induced Transcription Factor IL4 STAT antibody;Signal transducer and activator of transcription 6 antibody;Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced antibody;Signal Transducer And Activator Of Transcription 6 Nirs Variant 1 antibody;Signal transducer and activator of transcription 6, interleukin 4 induced antibody;STAT 6 antibody;STAT interleukin4 induced antibody;STAT, interleukin4 induced antibody;Stat6 antibody;STAT6_HUMAN antibody;STAT6B antibody;STAT6C antibody;Transcription factor IL 4 STAT antibody

SEQUENCE SIMILARITIES

Belongs to the transcription factor STAT family.

POST-TRANSLATIONAL MODIFICATION

Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4. Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.; Mono-ADP-ribosylated by PARP14.

SUBCELLULAR LOCATION

Cytoplasm, nucleus.

FUNCTION

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.