TRIF Recombinant Rabbit Monoclonal Antibody [PSH05-39]

Function

TIR domain containing adaptor molecule 1 (TICAM1; formerly known as TIR-domain-containing adapter-inducing interferon-β or TRIF) is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. Toll-like receptors (TLRs) recognize specific components of microbial invaders and activate an immune response to these pathogens. After these receptors recognize highly conserved pathogenic patterns, a downstream signaling cascade is activated in order to stimulate the release of inflammatory cytokines and chemokines as well as to upregulate the expression of immune cells. All TLRs have a TIR domain that initiates the signaling cascade through TIR adapters. Adapters are platforms that organize downstream signaling cascades leading to a specific cellular response after exposure to a given pathogen.

Background References

1. Muendlein HI et al. Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses. Sci Immunol. 2022 Dec

2. Pereira M et al. The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep. 2022 Aug

Subcellular Location

Cytoplasmic vesicle, autophagosome, Cytoplasm, cytosol, Mitochondrion.

UNIPROT

SwissProt: Q8IUC6 Human

SwissProt: Q80UF7 Mouse

Entrez Gene: 363328 Rat

Synonyms