Caveolin-1 Rabbit Polyclonal Antibody (0407-6)
Catalog# 0407-6
Rabbit Polyclonal to Caveolin-1
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WB
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IF-Cell
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IHC-P
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FC
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Human
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Mouse
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Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
Caveolin-1 Rabbit Polyclonal Antibody (0407-6)
Immunogen
Synthetic peptide within mouse caveolin-1 aa 128-178.
Host
Rabbit
Positive Control
Mouse liver tissue lysates, human kidney tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500
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IHC-P
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1:100
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 20 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Caveolin-1
SYNONYMS
BSCL3 antibody;CAV antibody;CAV1 antibody;CAV1_HUMAN antibody;caveolae protein, 22 kD antibody;caveolin 1 alpha isoform antibody;caveolin 1 beta isoform antibody;Caveolin 1 caveolae protein 22kDa antibody;Caveolin-1 antibody;Caveolin1 antibody;cell growth-inhibiting protein 32 antibody;CGL3 antibody;LCCNS antibody;MSTP085 antibody;OTTHUMP00000025031 antibody;PPH3 antibody;VIP 21 antibody;VIP21 antibody
SEQUENCE SIMILARITIES
Belongs to the caveolin family.
TISSUE SPECIFICITY
Adipose tissue, lung, heart, skeletal muscle, stomach, small bowel, kidney, spleen and testis (at protein level).
POST-TRANSLATIONAL MODIFICATION
The N-terminus of both isoforms are blocked.; Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.; Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.
SUBCELLULAR LOCATION
Golgi apparatus membrane, Cell membrane, Membrane, caveola, Membrane raft, Golgi apparatus, trans-Golgi network.
FUNCTION
Caveolin, an integral membrane protein, is a principal component of caveolae membranes in vivo. Two isoforms of caveolin have been identified: a slower migrating 24-kDa species (-isoform) and a faster migrating 21-kDa species (-isoform). Caveolins interact with multiple signaling molecules, such as the G-protein alpha subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases and eNOS. Caveolin-1 has been implicated in the pathogenesis of mammary epithelial cell hyperplasia.
CITATIONS
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Pan, Z., Wang, K., Wang, X., Jia, Z., Yang, Y., Duan, Y., Huang, L., Wu, Z. X., Zhang, J. Y., & Ding, X.
Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression
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WB
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Citation
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