CD10 Rabbit Polyclonal Antibody (0805-4)

UNIPROT #

P08473

PROTEIN NAME

CD10

SYNONYMS

Atriopeptidase antibody;CALLA antibody;CD10 antibody;CD10 antigen antibody;Common acute lymphocytic leukemia antigen antibody;DKFZp686O16152 antibody;EC 3.4.24.11 antibody;Enkephalinase antibody;EPN antibody;Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase) antibody;Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody;Membrane metallo endopeptidase antibody;Membrane metallo endopeptidase variant 1 antibody;Membrane metallo endopeptidase variant 2 antibody;Membrane metalloendopeptidase antibody;Membrane metalloendopeptidase neutral endopeptidase enkephalinase antibody;Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10 antibody;Membrane metalloendopeptidase variant 1 antibody;Membrane metalloendopeptidase variant 2 antibody;MGC126681 antibody;MGC126707 antibody;MME antibody;NEP antibody;NEP_HUMAN antibody;Neprilysin antibody;neprilysin-390 antibody;neprilysin-411 antibody;Neutral endopeptidase 24.11 antibody;Neutral endopeptidase antibody;Neutral endopeptidase, membrane-associated antibody;SFE antibody;Skin fibroblast elastase antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M13 family.

POST-TRANSLATIONAL MODIFICATION

Myristoylation is a determinant of membrane targeting.; Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.