ST2 Rabbit Polyclonal Antibody

Function

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.

Background References

1. Zhao, G., Ji, H., Wang, S., Gu, B., Song, X., Zhang, J., Zhang, M. (2014). Cell surface proteomics analysis indicates a neural lineage bias of rat bone marrow mesenchymal stromal cells. Biomed Res Int, 2014, 479269.

Sequence Similarity

Belongs to the interleukin-1 receptor family.

Tissue Specificity

Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Isoform A is expressed in brain astrocytes and microglia. Isoform B is expressed in brain endothelial cells.

Subcellular Location

Cell membrane, Secreted.

UNIPROT

SwissProt: Q01638 Human

SwissProt: P14719 Mouse

Synonyms