Prostate-Specific Antigen (PSA) Rabbit Polyclonal Antibody (ER1706-31)

UNIPROT #

P07288

PROTEIN NAME

Prostate-Specific Antigen (PSA)

SYNONYMS

antigen, prostate-specific antibody;APS antibody;Gamma seminoprotein antibody;Gamma-seminoprotein antibody;hK3 antibody;Kallikrein 3 antibody;Kallikrein related peptidase 3 antibody;Kallikrein-3 antibody;KLK 3 antibody;KLK2A1 antibody;Klk3 antibody;KLK3_HUMAN antibody;P-30 antigen antibody;P30 antigen antibody;Prostate-specific antigen antibody;Psa antibody;Semenogelase antibody;Seminin antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase S1 family. Kallikrein subfamily.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Prostate specific antigen (PSA), also designated γ-seminoprotein, seminin, p30 antigen, semenogelase, and kallikrein 3 (KLK3), was first identified as a glycoprotein in human seminal plasma. PSA was determined by sequence similarity to be a member of the kallikrein subfamily of trypsin proteases. PSA is a serine protease that hydrolyzes the major human seminal protein, the seminal plasma mobility inhibitor precursor, or semenogelin I (SPMIP or SgI), which leads to semen liquification. PSA production and expression are highest in normal, benign hyperplastic and cancerous tissues of the prostate, PSA has also been detected in accessory male sex glands and in breast cancer. PSA has been identified as an aid in the early detection of prostate cancer and is a commonly used tumor marker.