APC Rabbit Polyclonal Antibody (ER1802-39)

UNIPROT #

P25054

PROTEIN NAME

APC

SYNONYMS

Adenomatous Polyposis Coli antibody;Adenomatous polyposis coli protein antibody;Apc antibody;APC_HUMAN antibody;CC1 antibody;Deleted in polyposis 2.5 antibody;DP2 antibody;DP2.5 antibody;DP3 antibody;FAP antibody;FPC antibody;GS antibody;Protein APC antibody

SEQUENCE SIMILARITIES

Belongs to the adenomatous polyposis coli (APC) family.

TISSUE SPECIFICITY

Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver. Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues. Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by GSK3B.; Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID.

SUBCELLULAR LOCATION

Cell junction. Cytoplasm. Cytoskeleton. Membrane.

FUNCTION

The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2,843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. β-catenin and γ-catenin (also called plakoglobin), are involved in the regulation of cellular adhesion. APC and E-cadherin compete for binding to specific internal regions of both β- and γ-catenin. Interactions between cytoskeleton and the APC, E-cadherin, β/γ catenin complex are mediated by α-catenin.