CD45 Rabbit Polyclonal Antibody

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Background References

1. Rheinländer A. et. al. CD45 in human physiology and clinical medicine. Immunol Lett. 2018 Apr;196:22-32.

2. Fogle JE. et. al. CD45+ and CD45- lymphocyte populations identified by flow cytometry from dogs with lymphoma exhibit similar morphology and the same clonal (B cell or T cell) lineage. Vet Immunol Immunopathol. 2015 Dec 15;168(3-4):242-8.

Sequence Similarity

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.

Tissue Specificity

Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.

Post-translational Modification

Heavily N- and O-glycosylated.

Subcellular Location

Cell membrane, membrane raft.

UNIPROT

SwissProt: P08575 Human

Synonyms