AKT1/2/3 Recombinant Rabbit Monoclonal Antibody [ST48-09]
Catalog# ET1609-51
AKT1/2/3 Recombinant Rabbit Monoclonal Antibody [ST48-09]
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WB
-
IF-Cell
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IF-Tissue
-
IHC-P
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IP
-
FC
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IHC-Fr
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Human
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Mouse
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Rat
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Green monkey
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HA750179
不含抗保成分
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unconjugated
Overview
Product Name
AKT1/2/3 Recombinant Rabbit Monoclonal Antibody [ST48-09]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Recombinant protein within human AKT3 aa 300-479.
Species Reactivity
Human, Mouse, Rat, Green monkey
Validated Applications
WB, IF-Cell, IF-Tissue, IHC-P, IP, FC, IHC-Fr
Molecular Weight
Predicted band size: 56 kDa
Positive Control
MCF7 cell lysate, U-2 OS cell lysate, Jurkat cell lysate, C6 cell lysate, mouse heart tissue lysate, mouse testis tissue lysate, rat heart tissue lysate, rat testis tissue lysate, MCF7, RAW264.7, C6, human brain tissue, human lung tissue, mouse brain tissue, mouse lung tissue, rat brain tissue, rat lung tissue, mouse hippocampus tissue, mouse cerebral cortex tissue.
Conjugation
unconjugated
Clone Number
ST48-09
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1:5,000-1:10,000
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IF-Cell
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1:100-1:200
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IF-Tissue
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1:500-1:1,000
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IHC-P
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1:2,000
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FC
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1:1,000
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IP
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1-2μg/sample
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IHC-Fr
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1:100
Target
Function
The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKBβ or RacPK-β) and Akt 3 (also designated PKBγ or thyoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-β tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1(IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to generate a high level of Akt1 activity, and the phosphorylation of Thr 308 is not dependent on phosphorylation of Ser 473 in vivo. Thus, Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s). The activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin, suggesting that the protein signals downstream of the PI kinases.
Background References
1. Buendia, I. et al. 2015. The Melatonin-N,N-Dibenzyl(N-methyl)amine Hybrid ITH91/IQM157 Affords Neuroprotection in an in Vitro Alzheimer\'s Model via Hemo-oxygenase-1 Induction. ACS chemical neuroscience. 6: 288-96.
2. Siendones, E. et al. 2014. Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2. Antioxidants & redox signaling. 21: 1708-25.
Sequence Similarity
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
Tissue Specificity
Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
Post-translational Modification
O-GlcNAcylation at Thr-305 and Thr-312 inhibits activating phosphorylation at Thr-308 via disrupting the interaction between AKT1 and PDPK1. O-GlcNAcylation at Ser-473 also probably interferes with phosphorylation at this site.; Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Activated TNK2 phosphorylates it on Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. This phosphorylated form localizes to the cell membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308 and Ser-473 leading to its activation. Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1. Phosphorylated at Thr-308 and Ser-473 by IKBKE and TBK1. Ser-473 phosphorylation is enhanced by interaction with AGAP2 isoform 2 (PIKE-A). Ser-473 phosphorylation is enhanced in focal cortical dysplasias with Taylor-type balloon cells. Ser-473 phosphorylation is enhanced by signaling through activated FLT3 (By similarity). Ser-473 is dephosphorylated by PHLPP. Dephosphorylated at Thr-308 and Ser-473 by PP2A phosphatase. The phosphorylated form of PPP2R5B is required for bridging AKT1 with PP2A phosphatase. Ser-473 is dephosphorylated by CPPED1, leading to termination of signaling.; Ubiquitinated via 'Lys-48'-linked polyubiquitination by ZNRF1, leading to its degradation by the proteasome (By similarity). Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced 'Lys-63'-linked AKT1 ubiquitination is critical for phosphorylation and activation. When ubiquitinated, it translocates to the plasma membrane, where it becomes phosphorylated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome. Also ubiquitinated by TRIM13 leading to its proteasomal degradation. Phosphorylated, undergoes 'Lys-48'-linked polyubiquitination preferentially at Lys-284 catalyzed by MUL1, leading to its proteasomal degradation.; Acetylated on Lys-14 and Lys-20 by the histone acetyltransferases EP300 and KAT2B. Acetylation results in reduced phosphorylation and inhibition of activity. Deacetylated at Lys-14 and Lys-20 by SIRT1. SIRT1-mediated deacetylation relieves the inhibition.
Subcellular Location
Cell membrane, Cytoplasm, Membrane, Nucleus.
UNIPROT
Synonyms
AKT antibody
AKT1 antibody
AKT1 kinase antibody
AKT1m antibody
AKT2 antibody
AKT2 kinase antibody
Akt3 antibody
AKT3_HUMAN antibody
CAKT antibody
CWS6 antibody
ExpandImages
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Western blot analysis of AKT1/2/3 on different lysates with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/5,000 dilution.
Lane 1: MCF7 cell lysate (20 µg/Lane)
Lane 2: A549 cell lysate (20 µg/Lane)
Lane 3: U-2 OS cell lysate (20 µg/Lane)
Lane 4: COS-1 cell lysate (20 µg/Lane)
Lane 5: NIH/3T3 cell lysate (20 µg/Lane)
Lane 6: RAW264.7 cell lysate (20 µg/Lane)
Lane 7: C6 cell lysate (20 µg/Lane)
Lane 8: PC-12 cell lysate (20 µg/Lane)
Lane 9: Mouse brain tissue lysate (20 µg/Lane)
Lane 10: Mouse heart tissue lysate (20 µg/Lane)
Lane 11: Mouse testis tissue lysate (20 µg/Lane)
Lane 12: Rat brain tissue lysate (20 µg/Lane)
Lane 13: Rat heart tissue lysate (20 µg/Lane)
Lane 14: Rat testis tissue lysate (20 µg/Lane)
Predicted band size: 56 kDa
Observed band size: 56 kDa
Exposure time: 24 seconds; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (ET1609-51) at 1/5,000 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature. -
AKT1/2/3 was immunoprecipitated from 0.2 mg MCF7 cell lysate with ET1609-51 at 2 µg/10 µl beads. Western blot was performed from the immunoprecipitate using ET1609-51 at 1/1,000 dilution. Anti-Rabbit IgG for IP Nano-secondary antibody (NBI01H) at 1/5,000 dilution was used for 1 hour at room temperature.
Lane 1: MCF7 cell lysate (input)
Lane 2: ET1609-51 IP in MCF7 cell lysate
Lane 3: Rabbit IgG instead of ET1609-51 in MCF7 cell lysate
Blocking/Dilution buffer: 5% NFDM/TBST
Exposure time: 23 seconds; ECL: K1801 -
Immunocytochemistry analysis of MCF7 cells labeling AKT1/2/3 with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/100 dilution.
Cells were fixed in 4% paraformaldehyde for 20 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 5 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. Cells were then incubated with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/100 dilution in 1% BSA in PBST overnight at 4 ℃. Goat Anti-Rabbit IgG H&L (iFluor™ 488, HA1121) was used as the secondary antibody at 1/1,000 dilution. PBS instead of the primary antibody was used as the secondary antibody only control. Nuclear DNA was labelled in blue with DAPI.
Beta tubulin (M1305-2, red) was stained at 1/100 dilution overnight at +4℃. Goat Anti-Mouse IgG H&L (iFluor™ 594, HA1126) was used as the secondary antibody at 1/1,000 dilution. -
Immunocytochemistry analysis of RAW264.7 cells labeling AKT1/2/3 with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/100 dilution.
Cells were fixed in 4% paraformaldehyde for 20 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 5 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. Cells were then incubated with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/100 dilution in 1% BSA in PBST overnight at 4 ℃. Goat Anti-Rabbit IgG H&L (iFluor™ 488, HA1121) was used as the secondary antibody at 1/1,000 dilution. PBS instead of the primary antibody was used as the secondary antibody only control. Nuclear DNA was labelled in blue with DAPI.
Beta tubulin (M1305-2, red) was stained at 1/100 dilution overnight at +4℃. Goat Anti-Mouse IgG H&L (iFluor™ 594, HA1126) was used as the secondary antibody at 1/1,000 dilution. -
Immunocytochemistry analysis of C6 cells labeling AKT1/2/3 with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/100 dilution.
Cells were fixed in 4% paraformaldehyde for 20 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 5 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. Cells were then incubated with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/100 dilution in 1% BSA in PBST overnight at 4 ℃. Goat Anti-Rabbit IgG H&L (iFluor™ 488, HA1121) was used as the secondary antibody at 1/1,000 dilution. PBS instead of the primary antibody was used as the secondary antibody only control. Nuclear DNA was labelled in blue with DAPI.
Beta tubulin (M1305-2, red) was stained at 1/100 dilution overnight at +4℃. Goat Anti-Mouse IgG H&L (iFluor™ 594, HA1126) was used as the secondary antibody at 1/1,000 dilution. -
Immunohistochemical analysis of paraffin-embedded human brain tissue with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (ET1609-51) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded human lung tissue with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (ET1609-51) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded mouse brain tissue with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (ET1609-51) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded mouse lung tissue with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (ET1609-51) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded rat brain tissue with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (ET1609-51) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Immunohistochemical analysis of paraffin-embedded rat lung tissue with Rabbit anti-AKT1/2/3 antibody (ET1609-51) at 1/2,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (ET1609-51) at 1/2,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX. -
Application: IHC-Fr
Species: Mouse
Site: Hippocampus
Sample: Frozen section
Antibody concentration: 1/100
Antigen retrieval: The section was pre-treated using 1% SDS buffer (in PBS, pH 7.4) for 5 minutes at room temperature. -
Application: IHC-Fr
Species: Mouse
Site: Cerebral cortex
Sample: Frozen section
Antibody concentration: 1/100
Antigen retrieval: The section was pre-treated using 1% SDS buffer (in PBS, pH 7.4) for 5 minutes at room temperature. -
Flow cytometric analysis of MCF7 cells labeling AKT1/2/3.
Cells were fixed and permeabilized. Then stained with the primary antibody (ET1609-51, 1/1,000) (red) compared with Rabbit IgG Isotype Control (green). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a iFluor™ 488 conjugate-Goat anti-Rabbit IgG Secondary antibody (HA1121) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black). -
Flow cytometric analysis of RAW264.7 cells labeling AKT1/2/3.
Cells were fixed and permeabilized. Then stained with the primary antibody (ET1609-51, 1/1,000) (red) compared with Rabbit IgG Isotype Control (green). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a iFluor™ 488 conjugate-Goat anti-Rabbit IgG Secondary antibody (HA1121) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black). -
Flow cytometric analysis of C6 cells labeling AKT1/2/3.
Cells were fixed and permeabilized. Then stained with the primary antibody (ET1609-51, 1/1,000) (red) compared with Rabbit IgG Isotype Control (green). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a iFluor™ 488 conjugate-Goat anti-Rabbit IgG Secondary antibody (HA1121) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black).
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Citation
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Paeonol inhibits the development of oral squamous cell carcinoma through the PI3K/AKT signaling pathway
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DOI: 10.3389/fcell.2026.1747424
IF: 4.3
Application: WB
Reactivity: Human
Publish date: 2026 Mar
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DOI: 10.1002/mco2.70673
IF: 10.7
Application: WB
Reactivity: Mouse
Publish date: 2026 Mar
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Journal: Cell Reports Medicine
DOI: 10.1016/j.xcrm.2026.102650
IF: 10.6
Application: WB
Reactivity: Human
Publish date: 2026 Mar
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DOI: 10.1016/j.jep.2026.121482
IF: 5.4
Application: IHC
Reactivity: Mouse
Publish date: 2026 Mar
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DOI: 10.3390/ph19020195
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Application: WB
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Publish date: 2026 Jan
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IF: 8.3
Application: WB
Reactivity: Human
Publish date: 2026 Jan
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DOI: 10.1016/j.fitote.2025.107079
IF: 2.6
Application: WB
Reactivity: Human
Publish date: 2026 Jan
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IF: 5.8
Application: WB
Reactivity: Human
Publish date: 2026 Jan
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DOI: 10.1016/j.jff.2025.107131
IF: 4
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Reactivity: Mouse
Publish date: 2026 Jan
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IF: 2.5
Application: WB
Reactivity: Human
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Application: WB
Reactivity: Human
Publish date: 2026 Feb
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Application: WB
Reactivity: Human
Publish date: 2026 Feb
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DOI: 10.1007/s12032-026-03256-z
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Application: IHC
Reactivity: Mouse
Publish date: 2026 Feb
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IF: 5.4
Application: WB
Reactivity: Rat
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Application: WB
Reactivity: Mouse
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IF: 8.5
Application: WB
Reactivity: Human
Publish date: 2026 Feb
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Application: WB
Reactivity: Human,Mouse
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Application: WB
Reactivity: Human,Mouse
Publish date: 2026 Feb
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DOI: 10.3389/fphar.2025.1682550
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Application: WB
Reactivity: Human
Publish date: 2025 Sept
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Publish date: 2025 Sept
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IF: 5.4
Application: WB
Reactivity: Mouse
Publish date: 2025 Sept
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DOI: 10.1016/j.cej.2025.168176
IF: 13.2
Application: WB
Reactivity: Mouse
Publish date: 2025 Sept
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Isorhamnetin Exhibits Hypoglycemic Activity and Targets PI3K/AKT and COX-2 Pathways in Type 1 Diabetes
Journal: Nutrients
DOI: 10.3390/nu17203201
IF: 5
Application: WB
Reactivity: Mouse,Rat
Publish date: 2025 Oct
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In vitro and clinical evaluation of platelet-rich plasma combined with angioplasty in diabetic foot treatment
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DOI: 10.4239/wjd.v16.i10.110631
IF: 4.6
Application: WB
Reactivity: Human
Publish date: 2025 Oct
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Journal: Free Radical Biology And Medicine
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IF: 8.2
Application: WB
Reactivity: Human
Publish date: 2025 Oct
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IF: 9.7
Application: WB
Reactivity: Human
Publish date: 2025 Nov
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OpiCa1 Modulates Cardiomyocyte Viability Through PI3K/Akt Inhibition with Minimal Systemic Impact Beyond RyR Targeting
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DOI: 10.3390/toxins17110550
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Application: WB
Reactivity: Mouse,Rat
Publish date: 2025 Nov
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Paeoniflorin Alleviates LPS-Induced Inflammation and Acute Myocardial Injury by Inhibiting PI3K/Akt/ERK-Mediated HIF-1α and TLR4/MyD88/NF-κB Inflammatory Signaling
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DOI: 10.1155/mi/2346163
IF: 4.2
Application: WB
Reactivity: Rat
Publish date: 2025 Nov
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Dual interference with host neuropeptide signaling allows parasitoid wasp to hijack host sugar metabolism
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DOI: 10.1038/s44318-025-00636-5
IF: 8.3
Application: WB
Reactivity: Plutella xylostella
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CUEDC1 promotes glycolytic metabolism reprogramming through the CUEDC1/CACNG4/PI3K axis to promote ER-positive breast cancer growth
Journal: Cellular & Molecular Biology Letters
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IF: 10.2
Application: WB
Reactivity: Human,Mouse
Publish date: 2025 Nov
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Sensory neuron TRPV1-mediated macrophage polarization and immune response regulate dental implant osseointegration
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Ultra-Small Coordination Dihydromyricetin Nanodots Attenuate Alveolar Bone Resorption in Periodontitis Through Inhibition of ITGB3-Driven Osteoclast Differentiation
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IF: 10.2
Application: WB
Reactivity: Mouse
Publish date: 2025 Nov
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IF: 6
Application: WB
Reactivity: Mouse
Publish date: 2025 May
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IF: 8.5
Application: WB
Reactivity: Mouse
Publish date: 2025 May
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DOI: 10.3390/ph18030428
IF: 4.3
Application: WB
Reactivity: Human
Publish date: 2025 Mar
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Trimethylamine N-oxide (TMAO) treatment triggers premature ovarian insufficiency (POI) via the activation of mitochondrial pathway apoptosis in granulosa cells
Journal: FREE RADICAL BIOLOGY AND MEDICINE
DOI: 10.1016/j.freeradbiomed.2025.03.007
IF: 8.2
Application: WB
Reactivity: Mouse
Publish date: 2025 Mar
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DOI: 10.3389/fphys.2025.1529811
IF: 3.2
Application: WB
Reactivity: Rat
Publish date: 2025 Mar
-
A novel PEGylated squid-derived protamine protein in combination with sorafenib effectively inhibits hepatocellular carcinoma growth
Journal: International Journal Of Biological Macromolecules
DOI: 10.1016/j.ijbiomac.2025.145283
IF: 8.5
Application: WB
Reactivity: Mouse
Publish date: 2025 Jun
-
Biomaterial-Based Lymphangiogenesis-Enhanced Therapeutic Strategy for Robustly-Integrated Medication-Related Osteonecrosis of Jaw Prevention
Journal: ACS Applied Materials & Interfaces
DOI: 10.1021/acsami.5c02812
IF: 8.2
Application: WB
Reactivity: Human
Publish date: 2025 Jun
-
High mobility group box 1, a novel serotonin receptor-7 negative modulator, contributes to M2 microglial ferroptosis and neuroinflammation in post-stroke depression
Journal: Free Radical Biology And Medicine
DOI: 10.1016/j.freeradbiomed.2025.06.025
IF: 8.2
Application: WB
Reactivity: Mouse
Publish date: 2025 Jun
-
POLR2H Serves as a Novel Prognostic Biomarker Correlated with Immune Infiltration in Prostate Cancer
Journal: Biochemical Genetics
DOI: 10.1007/s10528-025-11150-y
IF: 1.6
Application: WB
Reactivity: Human
Publish date: 2025 Jun
-
Quinolinone Derivatives Suppress Angiogenesis in Human Umbilical Vein Endothelial Cells by Blocking the VEGF-Induced VEGFR2 Signaling Pathway
Journal: Archiv Der Pharmazie
DOI: 10.1002/ardp.70040
IF: 3.6
Application: WB
Reactivity: Human
Publish date: 2025 Jul
-
Ursolic and oleanolic acids suppress MNNG induced malignant transformation of human gastric mucosal epithelium by regulating the PI3 K/AKT pathway
Journal: Scientific Reports
DOI: 10.1038/s41598-025-03606-3
IF: 3.9
Application: WB
Reactivity: Human
Publish date: 2025 Jul
-
Probiotic efficacy of Cetobacterium somerae (CGMCC No. 28843): promoting intestinal digestion, absorption, and structural integrity in juvenile grass carp (Ctenopharyngodon idella)
Journal: Journal of Animal Science and Biotechnology
DOI: 10.1186/s40104-025-01224-7
IF: 6.5
Application: WB
Reactivity: Fish
Publish date: 2025 Jul
-
Exploring SERTAD4 as a prognostic biomarker and therapeutic target in breast cancer: insights from multidatabase analyses and in vitro studies
Journal: Clinical And Experimental Medicine
DOI: 10.1007/s10238-025-01792-y
IF: 3.5
Application: WB
Reactivity: Human
Publish date: 2025 Jul
-
STING1 targets MYH9 to drive adipogenesis through the AKT/GSK3β/β-catenin pathway
Journal: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI: 10.1016/j.bbrc.2025.151352
IF: 2.2
Application: WB
Reactivity: Mouse
Publish date: 2025 Jan
-
Gestational diabetes mellitus-derived miR-7-19488 targets PIK3R2 mRNA to stimulate the abnormal development and maturation of offspring-islets
Journal: LIFE SCIENCES
DOI: 10.1016/j.lfs.2025.123369
IF: 5.1
Application: WB
Reactivity: Rat
Publish date: 2025 Jan
-
STING1 targets MYH9 to drive adipogenesis through the AKT/GSK3β/β-catenin pathway
Journal: Biochemical And Biophysical Research Communications
DOI:
IF: 2.5
Application: WB
Reactivity: Mouse
Publish date: 2025 Jan
-
Serum Pharmacochemistry and Network Pharmacology Reveal Active Compounds and Mechanisms of the Huaxian Formula in Alleviating Radiation-Induced Pulmonary Fibrosis
Journal: Drug Design Development and Therapy
DOI: 10.2147/DDDT.S490844
IF: 5.1
Application: WB
Reactivity: Mouse
Publish date: 2025 Jan
-
Gestational diabetes mellitus-derived miR-7-19488 targets PIK3R2 mRNA to stimulate the abnormal development and maturation of offspring-islets
Journal: Life Sciences
DOI:
IF: 5.2
Application: WB
Reactivity: Rat
Publish date: 2025 Jan
-
NACC1 accelerates the progression of AML by regulating the ADAM9/PI3K/AKT axis
Journal: International Journal Of Medical Sciences
DOI:
IF: 3.2
Application: WB
Reactivity: Human
Publish date: 2025 Jan
-
NACC1 accelerates the progression of AML by regulating the ADAM9/PI3K/AKT axis
Journal: International Journal of Medical Sciences
DOI: 10.7150/ijms.102266
IF: 3.2
Application: WB
Reactivity: Human
Publish date: 2025 Jan
-
Isorhamnetin Alleviates Inflammation-Induced Crosstalk between Kynurenine Pathway and Gut Microbiota in Depressed Mice
Journal: Biomolecules & Therapeutics
DOI: 10.4062/biomolther.2024.061
IF: 3
Application: WB
Reactivity: Mouse
Publish date: 2025 Feb
-
Total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack prevents acetaminophen-induced liver injury by activating Keap1/Nrf2 and PI3K/AKT/mTOR signaling pathway
Journal: Journal Of Ethnopharmacology
DOI: 10.1016/j.jep.2025.119562
IF: 4.8
Application: WB
Reactivity: Mouse
Publish date: 2025 Feb
-
Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways
Journal: Journal Of Gene Medicine
DOI: 10.1002/jgm.70011
IF: 3.2
Application: WB
Reactivity: Human
Publish date: 2025 Feb
-
Targeting periodontal inflammatory microenvironment to ameliorate periodontitis: A nitrogen ions implantation technique
Journal: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.116055
IF: 4.7
Application: WB,IHC
Reactivity: Mouse
Publish date: 2025 Dec
-
Elucidating the Role of PBRM1 in NPC via RNA-seq Transcriptomic Sequencing
Journal: SLAS Technology
DOI: 10.1016/j.slast.2025.100386
IF: 3.7
Application: WB
Reactivity: Human
Publish date: 2025 Dec
-
HIF-1α regulates the proliferation and differentiation of mouse cranial base sphenoid-occipital synchondrosis chondrocytes via PI3K/Akt signaling
Journal: Scientific Reports
DOI: 10.1038/s41598-025-11055-1
IF: 3.9
Application: WB
Reactivity: Mouse
Publish date: 2025 Aug
-
Integrating network pharmacology and experimental validation to explore the mechanism of Yiqi Ziyin in treating immune thrombocytopenia
Journal: Scientific Reports
DOI: 10.1038/s41598-025-14105-w
IF: 3.9
Application: WB
Reactivity: Mouse
Publish date: 2025 Aug
-
CDCP1 knockdown suppresses PDGFRβ/AKT pathway-mediated vascular smooth muscle cell proliferation by inhibiting PDGFRβ endocytosis
Journal: Peer J
DOI: 10.7717/peerj.19114
IF: 2.3
Application: WB
Reactivity: Mouse
Publish date: 2025 Apr
-
Enhanced migration and adhesion protein expression by polyethylene glycol 4-modified SVVYGLR peptide in an in vitro human gingival fibroblast wound healing model
Journal: Folia Histochemica Et Cytobiologica
DOI: 10.5603/fhc.104010
IF: 1.7
Application: WB
Reactivity: Mouse
Publish date: 2025 Apr
-
Loss of lims1 causes aberrant cardiac remodeling and heart failure via activating gp130/Jak1/Stat3 pathway in zebrafish
Journal: Journal of Genetics and Genomics
DOI: 10.1016/j.jgg.2025.04.003
IF: 6.6
Application: WB
Reactivity: Zebrafish
Publish date: 2025 Apr
-
Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis
Journal: Journal Of Nanobiotechnology
DOI: 10.1186/s12951-025-03343-9
IF: 10.6
Application: WB
Reactivity: Mouse
Publish date: 2025 Apr
-
Quercetin inhibited LPS-induced cytokine storm by interacting with the AKT1-FoxO1 and Keap1-Nrf2 signaling pathway in macrophages
Journal: Scientific Reports
DOI: 10.1038/s41598-024-71569-y
IF: 3.8
Application: WB
Reactivity: Mouse
Publish date: 2024 Sept
-
Framework Nucleic Acids Loaded with Quercetin: Protecting Retinal Neurovascular Unit via the Protein Kinase B/Heme Oxygenase-1 Pathway
Journal: ACS Applied Nano Materials
DOI:
IF: 15.8
Application: WB
Reactivity: Mouse
Publish date: 2024 Sep
-
Genipin promotes the apoptosis and autophagy of neuroblastoma cells by suppressing the PI3K/AKT/mTOR pathway
Journal: Scientific Reports
DOI:
IF: 3.8
Application: WB
Reactivity: Human
Publish date: 2024 Sep
-
Sulindac (K-80003) with nab-paclitaxel and gemcitabine overcomes drug-resistant pancreatic cancer
Journal: Molecular Cancer
DOI:
IF: 27.7
Application: WB
Reactivity: Human
Publish date: 2024 Oct
-
Chaperonin-containing TCP1 subunit 6A inhibition via TRIM21-mediated K48-linked ubiquitination suppresses triple-negative breast cancer progression through the AKT signalling pathway
Journal: Clinical And Translational Medicine
DOI: 10.1002/ctm2.70097
IF: 7.9
Application: WB
Reactivity: Human
Publish date: 2024 Nov
-
Exploring the Osteogenic Effects of Simiao Wan through Activation of the PI3K/AKT Pathway in Osteoblasts
Journal: Journal Of Ethnopharmacology
DOI:
IF: 4.8
Application: WB
Reactivity: Mouse
Publish date: 2024 Nov
-
Resveratrol alleviates depression-like behaviors by inhibiting ferroptosis via AKT/NRF2 pathway
Journal: Brain Research Bulletin
DOI:
IF: 3.5
Application: WB
Reactivity: Rat
Publish date: 2024 Nov
-
Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds
Journal: World Journal Of Diabetes
DOI:
IF: 4.2
Application: WB
Reactivity: Human
Publish date: 2024 Nov
-
SORBS1 inhibits epithelial to mesenchymal transition (EMT) of breast cancer cells by regulating PI3K/AKT signaling and macrophage phenotypic polarization
Journal: Aging-Us
DOI: 10.18632/aging.205632
IF: 3.9
Application: WB
Reactivity: Human
Publish date: 2024 Mar
-
Identification of SARS-CoV-2-specific T cell and its receptor
Journal: Journal Of Hematology & Oncology
DOI:
IF: 29.5
Application: WB
Reactivity: Human
Publish date: 2024 Mar
-
A novel L-shaped ortho-quinone analog suppresses glioblastoma progression by targeting acceleration of AR degradation and regulating PI3K/AKT pathway
Journal: Biochemical Pharmacology
DOI: 10.1016/j.bcp.2024.116398
IF: 5.3
Application: WB
Reactivity: Human
Publish date: 2024 Jun
-
Inhibiting PRMT1 protects against CoNV by regulating macrophages through the FGF2/PI3K/Akt pathway
Journal: European Journal Of Pharmacology
DOI:
IF: 5
Application: WB
Reactivity: Mouse
Publish date: 2024 Jun
-
Extracellular Vesicles Containing GAS6 Protect the Liver from Ischemia-Reperfusion Injury by Enhancing Macrophage Efferocytosis via MerTK-ERK-COX2 Signaling
Journal: Preprint And Has Not Been Certified By Peer Review
DOI:
IF:
Application: WB
Reactivity: Mouse
Publish date: 2024 Jun
-
Engineered-Doping Strategy for Self-Sufficient Reactive Oxygen Species Blossom to Amplify Ferroptosis/Cuproptosis Sensibilization in Hepatocellular Carcinoma Treatment
Journal: Advanced Functional Materials
DOI:
IF: 19.9
Application: WB
Reactivity: Human
Publish date: 2024 Jun
-
HNRNP I promotes IRAK1 degradation to reduce podocyte apoptosis and inflammatory response alleviating renal injury in diabetic nephropathy
Journal: Immunobiology
DOI:
IF: 2.5
Application: WB
Reactivity: Human
Publish date: 2024 Jul
-
Disintegrin Accutin inhibits A549 cell migration though suppression of EMT and FAK/AKT signaling pathway
Journal: International Journal Of Biological Macromolecules
DOI:
IF: 7.7
Application: WB
Reactivity: Human
Publish date: 2024 Jul
-
Enhancing the therapeutic efficacy of gefitinib on subcutaneously transplanted SKOV3 ovarian cancer tumors in nude mice via ultrasound‑stimulated microbubble cavitation
Journal: Experimental And Therapeutic Medicine
DOI:
IF: 2.4
Application: WB
Reactivity: Mouse
Publish date: 2024 Jul
-
The Therapeutic Potential of Chi Shao and Fu Zi in Acute-on-Chronic Liver Failure: Insights from Network Pharmacology and Animal Studies
Journal: Preprint And Has Not Been Certified By Peer Review
DOI:
IF:
Application: WB
Reactivity: Rat
Publish date: 2024 Jul
-
Hyperuricemia Induces Reproductive Damage in Male Rats through Zinc Homeostasis Imbalance and Oxidative Stress
Journal: Andrology
DOI:
IF: 2.5
Application: WB
Reactivity: Rat
Publish date: 2024 Jan
-
Effect of Sonic hedgehog gene-modified bone marrow mesenchymal stem cells on graft-induced retinal gliosis and retinal ganglion cells survival in diabetic mice
Journal: International Journal Of Ophthalmology
DOI: 10.18240/ijo.2024.01.05
IF: 1.9
Application: WB
Reactivity: Mouse
Publish date: 2024 Jan
-
Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo
Journal: European Journal Of Medicinal Chemistry
DOI: 10.1016/j.ejmech.2024.116209
IF: 6
Application: WB
Reactivity: Human
Publish date: 2024 Feb
-
Sulforaphane inhibits multiple myeloma cell-induced osteoclast differentiation and macrophage proliferation by elevating ferroportin1
Journal: Cancer Chemotherapy And Pharmacology
DOI:
IF: 2.7
Application: WB
Reactivity: Human
Publish date: 2024 Dec
-
Regulation of Glycolysis-Derived L-lactate Production in Astrocytes Rescues the Memory Deficits and Aβ Burden in Early Alzheimer's Disease Models
Journal: Pharmacological Research
DOI:
IF: 9.1
Application: WB
Reactivity: Mouse
Publish date: 2024 Aug
-
Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions
Journal: Biomaterials
DOI:
IF: 14
Application: WB
Reactivity: Human,Mouse
Publish date: 2024 Apr
-
Rhein‐based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization
Journal: Aggregate
DOI:
IF: 18.8
Application: WB
Reactivity: Human
Publish date: 2024 Apr
-
Enhancing metformin-induced tumor metabolism destruction by glucose oxidase for triple-combination therapy
Journal: Journal Of Pharmaceutical Analysis
DOI: 10.1016/j.jpha.2023.09.015
IF: 8.8
Application: WB
Reactivity: Mouse
Publish date: 2023 Sept
-
LncRNA RP11-93B14. 5 promotes gastric cancer cell growth through PI3K/AKT signaling pathway
Journal: Molecular Biotechnology
DOI:
IF: 2.6
Application: WB
Reactivity: Human
Publish date: 2023 Sept
-
Antibacterial and Angiogenic (2A) Bio-Heterojunctions Facilitate Infectious Ischemic Wound Regeneration via an Endogenous-Exogenous Bistimulatory Strategy
Journal: Advanced Materials
DOI:
IF: 29.4
Application: WB
Reactivity: Mouse
Publish date: 2023 Oct
-
dCas9-Based PDGFR-β Activation ADSCs Accelerate Wound Healing in Diabetic Mice through Angiogenesis and ECM Remodeling
Journal: International Journal Of Molecular Sciences
DOI:
IF: 6.208
Application: WB
Reactivity: Mouse,Human
Publish date: 2023 Mar
-
GLP‑1 receptor agonist protects palmitate-induced insulin resistance in skeletal muscle cells by up-regulating sestrin2 to promote autophagy
Journal: Scientific Reports
DOI:
IF: 4.996
Application: WB
Reactivity: Rat
Publish date: 2023 Jun
-
Mechanisms of action underlying the effect of Tongsaimai on wound healing based on experimental and network pharmacology
Journal: Journal Of Ethnopharmacology
DOI:
IF: 5.195
Application: WB
Reactivity: Mouse
Publish date: 2023 Jul
-
Tetrahedral framework nucleic acids inhibit pathological neovascularization and vaso-obliteration in ischaemic retinopathy via PI3K/AKT/mTOR signalling pathway
Journal: Cell Proliferation
DOI:
IF:
Application: WB
Reactivity: Human
Publish date: 2023 Jan
-
Upregulation of glutamate transporter 1 by mTOR/Akt pathway in astrocyte culture during oxygen-glucose deprivation and reoxygenation
Journal: Experimental Brain Research
DOI:
IF: 2
Application: WB
Reactivity: Rat
Publish date: 2023 Jan
-
Carvedilol exhibits anti-acute T lymphoblastic leukemia effect in vitro and in vivo via inhibiting β-ARs signaling pathway
Journal: Biochemical And Biophysical Research Communications
DOI:
IF: 3.1
Application: WB
Reactivity: Human
Publish date: 2023 Jan
-
Icariin improves learning and memory function in Aβ1-42-induced AD mice through regulation of the BDNF-TrκB signaling pathway
Journal: Journal Of Ethnopharmacology
DOI: 10.1016/j.jep.2023.117029
IF: 5.4
Application: WB
Reactivity: Mouse
Publish date: 2023 Aug
-
Circular RNA hsa_circ_0084054 promotes the progression of periodontitis with diabetes via the miR‐508‐3p/PTEN axis
Journal: Journal Of Periodontal Research
DOI:
IF: 3.5
Application: WB
Reactivity: Human
Publish date: 2023 Aug
-
Downregulation of fibulin-4 inhibits autophagy and promotes the sensitivity of esophageal squamous cell carcinoma cells to apatinib by activating the Akt-mTOR signaling pathway
Journal: Thoracic Cancer
DOI:
IF: 3.223
Application: WB
Reactivity: Human
Publish date: 2022 Sept
-
Ozone causes depressive-like response through PI3K/Akt/GSK3β pathway modulating synaptic plasticity in young rats
Journal: Ecotoxicology And Environmental Safety
DOI: 10.1016/j.ecoenv.2022.114171
IF: 7.129
Application: WB
Reactivity: Rat
Publish date: 2022 Oct
-
Icariin alleviates osteoarthritis through PI3K/Akt/mTOR/ULK1 signaling pathway
Journal: European Journal Of Medical Research
DOI:
IF: 4.981
Application: WB
Reactivity: Human
Publish date: 2022 Oct
-
Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens
Journal: Cells
DOI:
IF: 7.666
Application: WB
Reactivity: Chicken
Publish date: 2022 Oct
-
N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma
Journal: Molecular Cancer
DOI:
IF: 41.444
Application: WB
Reactivity: Human
Publish date: 2022 May
-
Estradiol reduced 5-HT reuptake by downregulating the gene expression of Plasma Membrane Monoamine Transporter (PMAT, Slc29a4) through estrogen receptor β and the MAPK/ERK signaling pathway
Journal: European Journal Of Pharmacology
DOI:
IF: 4.432
Application: WB
Reactivity: Rat
Publish date: 2022 Jun
-
PD-L1 regulates cell proliferation and apoptosis in acute myeloid leukemia by activating PI3K-AKT signaling pathway
Journal: Scientific Reports
DOI:
IF: 4.380
Application: WB
Reactivity: Human
Publish date: 2022 Jul
-
PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis
Journal: Cell Death & Disease
DOI:
IF: 8.469
Application: WB
Reactivity: Human
Publish date: 2022 Feb
-
Ginsenoside Rk1 Prevents UVB Irradiation-Mediated Oxidative Stress, Inflammatory Response, and Collagen Degradation via the PI3K/AKT/NF-κB Pathway In Vitro and In Vivo
Journal: Journal Of Agricultural And Food Chemistry
DOI:
IF: 6.1
Application: WB
Reactivity: Human
Publish date: 2022 Dec
-
Nickel nanoparticles affect the migration and invasion of HTR-8/SVneo cells by downregulating MMP2 through the PI3K/AKT pathway
Journal: Toxicology In Vitro
DOI:
IF: 3.2
Application: WB
Reactivity: Human
Publish date: 2022 Apr
-
Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery
Journal: Bioactive Materials
DOI:
IF: 14.594
Application: WB
Reactivity: Rat
Publish date: 2021 Jun
-
Uncovering the mechanisms of leech and centipede granules in the treatment of diabetes mellitus-induced erectile dysfunction utilising network pharmacology
Journal: Journal Of Ethnopharmacology
DOI:
IF: 5.4
Application: WB
Reactivity: Rat
Publish date: 2021 Jan
-
Tumor Suppressor Functions of miRNA-375 in Nasopharyngeal Carcinoma through Inhibition of Ubiquitin-Specific Protease 1 Expression
Journal: International Journal Of Biochemistry And Cell Biology
DOI:
IF: 5.09
Application: WB
Reactivity: Human
Publish date: 2021 Dec
-
Inhibition of the activation of γδT17 cells throughPPARγ–PTEN/Akt/GSK3β/NFAT pathwaycontributes to the anti-colitis effect of madecassicacid
Journal: Cell Death & Disease
DOI:
IF: 6.30
Application: WB
Reactivity: Mouse
Publish date: 2020 Sept
-
Metformin Prevents Follicular Atresia in Aging Laying Chickens through Activation of PI3K/AKT and Calcium Signaling Pathways
Journal: Oxidative Medicine And Cellular Longevity
DOI:
IF: 5.076
Application: WB,IHC-P
Reactivity: Chicken
Publish date: 2020 Nov
-
CD44 inhibition attenuates EGFR signaling and enhances cisplatin sensitivity in human EGFR wild-type non-small-cell lung cancer cells
Journal: International Journal Of Molecular Medicine
DOI:
IF: 2.928
Application: WB
Reactivity: Human
Publish date: 2020 Jun
-
Cul4 E3 ubiquitin ligase regulates ovarian cancer drug resistance by targeting the antiapoptotic protein BIRC3
Journal: Cell Death & Disease
DOI:
IF: 5.64
Application: WB
Reactivity: Human
Publish date: 2019 Feb
-
Knockdown of ISOC1 inhibits the proliferation and migration and induces the apoptosis of colon cancer cells through the AKT/GSK-3β pathway
Journal: Carcinogenesis
DOI:
IF: 4.004
Application: WB
Reactivity: Human
Publish date: 2019 Aug
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AKT1/2/3 Recombinant Rabbit Monoclonal Antibody [JE75-09]
Application: WB,IF-Cell,FC,IP
Reactivity: Human,Mouse,Rat,Green monkey
Conjugate: unconjugated
AKT1/2/3 Recombinant Rabbit Monoclonal Antibody [ST48-09] - BSA and Azide free
Application: WB,IF-Cell,IF-Tissue,IHC-P,IP,FC,IHC-Fr
Reactivity: Human,Mouse,Rat,Green monkey
Conjugate: unconjugated
AKT1/2/3 Recombinant Rabbit Monoclonal Antibody [JE75-09] - BSA and Azide free
Application: WB,IF-Cell,FC,IP
Reactivity: Human,Mouse,Rat,Green monkey
Conjugate: unconjugated
