VE Cadherin Recombinant Rabbit Monoclonal Antibody [JJ0941]

Function

The cadherins are a family of Ca²⁺-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy-terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including β-catenin, to regulate cadherin function. VE-cadherin (for vascular endothelial cadherin, also designated cadherin-5) is localized at intercellular junctions of endothelial cells, where it is thought to play a role in the cohesion and organization of intercellular junctions.

Background References

1. Ye X et al. Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma. J Pathol 239:139-51 (2016).

2. Li C et al. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. Nat Commun 7:11455 (2016).

Tissue Specificity

Expressed in postnatal endothelial cells of the retinal vascular plexus (at protein level).

Post-translational Modification

Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.; O-glycosylated.

Subcellular Location

Cell junction, Cell membrane.

UNIPROT

SwissProt: P55284 Mouse

Synonyms