Cyclin D2 Rabbit Polyclonal Antibody

Function

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).

Background References

1. Petkova SP. et. al. Cyclin D2-knock-out mice with attenuated dentate gyrus neurogenesis have robust deficits in long-term memory formation. Sci Rep. 2020 May

2. Luckey SW. et. al. Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy. Exp Biol Med (Maywood). 2017 Dec

Subcellular Location

Nucleus, Cytoplasm, Nucleus membrane.

UNIPROT

SwissProt: P30279 Human

SwissProt: P30280 Mouse

SwissProt: Q04827 Rat

Synonyms

CCND 2 antibody

ccnd2 antibody

CCND2_HUMAN antibody

CyclinD2 antibody

G1/S specific cyclin D2 antibody

G1/S-specific cyclin-D2 antibody

KIAK0002 antibody

MGC102758 antibody

MPPH3 antibody