TATA binding protein TBP Rabbit Polyclonal Antibody (HA500518)

UNIPROT #

P20226

PROTEIN NAME

TATA binding protein TBP

SYNONYMS

GTF2D antibody;GTF2D1 antibody;HDL4 antibody;MGC117320 antibody;MGC126054 antibody;MGC126055 antibody;SCA17 antibody;TATA binding factor antibody;TATA box factor antibody;TATA sequence binding protein antibody;TATA sequence-binding protein antibody;TATA-binding factor antibody;TATA-box binding protein N-terminal domain antibody;TATA-box factor antibody;TATA-box-binding protein antibody;TBP antibody;TBP_HUMAN antibody;TFIID antibody;Transcription initiation factor TFIID TBP subunit antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP is a member of a small gene family of TBP-related factors. The first TBP-related factor (TRF/TRF1) was identified in the fruit fly Drosophila, but appears to be fly or insect-specific. Subsequently TBPL1/TRF2 was found in the genomes of many metazoans, whereas vertebrate genomes encode a third vertebrate family member, TBPL2/TRF3. In specific cell types or on specific promoters TBP can be replaced by one of these TBP-related factors, some of which interact with the TATA box similarly to TBP.