Mouse CD45R/B220 Recombinant Rat Monoclonal Antibody [PSH10-80]

Function

CD45R (also known as B220) is an isoform of CD45 (PTPRC), a member of the protein tyrosine phosphatase (PTP) family with an apparent molecular weight of 180–240 kDa due to extensive glycosylation. CD45R is expressed throughout B cell development, from pro-B to mature B cells, and is therefore widely used as a pan-B cell marker in mice. However, it is not entirely B cell-specific, as it is also expressed on subsets of activated T cells, NK cells, and plasmacytoid dendritic cells. CD45R is also found on abnormal T cell populations in autoimmune-prone mouse models such as MRL-Faslpr and MRL-Fasgld mice. Functionally, CD45 plays a critical role in antigen receptor signaling by regulating Src family kinases (e.g., Lck and Fyn) through its tyrosine phosphatase activity, rather than acting via classical ligand–receptor interactions.

Background References

1. Albekairi TH et al. Cadmium exposure exacerbates immunological abnormalities in a BTBR T(+) Itpr3(tf)/J autistic mouse model by upregulating inflammatory mediators in CD45R-expressing cells. J Neuroimmunol. 2024 Jan

2. Farombi EO et al. Kolaviron ameliorates behavioural deficit and injury to striatal dopaminergic terminals via modulation of oxidative burden, DJ-1 depletion and CD45R(+) cells infiltration in MPTP-model of Parkinson\'s disease. Metab Brain Dis. 2020 Aug

Subcellular Location

Cell membrane, Membrane raft, Synapse.

UNIPROT

SwissProt: P06800 Mouse

Synonyms